Literature DB >> 16908969

Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application.

Pawel Kermer1, Jan Liman, Jochen H Weishaupt, Mathias Bähr.   

Abstract

In recent years, the investigation of erroneous regulation of apoptotic mechanisms during acute and chronic injury of neuronal cells has gained increasing attention. Besides acute neuronal trauma and ischemia, chronic neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's and Lou-Gehrig's disease (amyotrophic lateral sclerosis) are of particular interest. The present article will provide an overview of basic apoptotic mechanisms, the contribution of neuronal apoptosis to the above-mentioned disorders, potential clinical applications and their limitations and the possible implications for future studies regarding these neurodegenerative diseases. Copyright (c) 2004 S. Karger AG, Basel.

Entities:  

Mesh：

Year:  2004        PMID： 16908969     DOI： 10.1159/000076665

Source DB:  PubMed          Journal:  Neurodegener Dis        ISSN： 1660-2854            Impact factor:   2.977


  21 in total

1.  Biophotonic probing of macromolecular transformations during apoptosis.

Authors:  Artem Pliss; Andrey N Kuzmin; Aliaksandr V Kachynski; Paras N Prasad
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-06       Impact factor: 11.205

2.  Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats.

Authors:  Chin-yi Cheng; Shan-yu Su; Nou-ying Tang; Tin-yun Ho; Wan-yu Lo; Ching-liang Hsieh
Journal:  Acta Pharmacol Sin       Date:  2010-07-19       Impact factor: 6.150

3.  Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity.

Authors:  Aracely Garcia-Garcia; Annandurai Anandhan; Michaela Burns; Han Chen; You Zhou; Rodrigo Franco
Journal:  Toxicol Sci       Date:  2013-08-31       Impact factor: 4.849

4.  Bax inhibitor-1 protects neurons from oxygen-glucose deprivation.

Authors:  Christoph P Dohm; Sandra Siedenberg; Jan Liman; Alessandro Esposito; Fred S Wouters; John C Reed; Mathias Bähr; Pawel Kermer
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

Review 5.  [Programmed cell death in the retina. Molecular mechanisms and therapeutic strategies].

Authors:  P Kermer; M Bähr
Journal:  Ophthalmologe       Date:  2005-07       Impact factor: 1.059

Review 6.  Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies.

Authors:  Avraham Mayevsky; Efrat Barbiro-Michaely
Journal:  J Clin Monit Comput       Date:  2012-12-01       Impact factor: 2.502

7.  Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts.

Authors:  Rijin Xiao; Amy L Ferry; Esther E Dupont-Versteegden
Journal:  Apoptosis       Date:  2011-03       Impact factor: 4.677

8.  A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.

Authors:  Sheila J Semaan; Yan Li; Robert W Nickells
Journal:  ASN Neuro       Date:  2010-03-31       Impact factor: 4.146

Review 9.  Recent advances in our understanding of neurodegeneration.

Authors:  Kurt A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2009-06-05       Impact factor: 3.575

Review 10.  Sumoylation in neurodegenerative diseases.

Authors:  Petranka Krumova; Jochen H Weishaupt
Journal:  Cell Mol Life Sci       Date:  2012-09-25       Impact factor: 9.261
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