| Literature DB >> 1690896 |
G Siegel1, J Mironneau, F Schnalke, G Schröder, B G Schulz, J Grote.
Abstract
In arterial smooth muscle with normal tone or predepolarized and precontracted by noradrenaline, iloprost effects a dose-dependent hyperpolarization and relaxation. The hyperpolarization is due to K+ channel opening. In hypoxic vasodilatation, which is likewise induced by membrane hyperpolarization, a share of 20-30% falls to prostacyclin and 70-80% to an endothelium-derived hyperpolarizing factor.Entities:
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Year: 1990 PMID： 1690896
Source DB: PubMed Journal: Prog Clin Biol Res ISSN： 0361-7742