Literature DB >> 16908150

Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.

Jesper F Lau1, Claus Bekker Jeppesen, Karin Rimvall, Rolf Hohlweg.   

Abstract

A group of tri and tetrasubstituted urea derivatives have been found to be hH(3)-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.

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Year:  2006        PMID: 16908150     DOI: 10.1016/j.bmcl.2006.07.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides.

Authors:  Andrii Lozynskyi; Borys Zimenkovsky; Roman Lesyk
Journal:  Sci Pharm       Date:  2014-09-15

2.  Comparison of Different 2D and 3D-QSAR Methods on Activity Prediction of Histamine H3 Receptor Antagonists.

Authors:  Siavoush Dastmalchi; Maryam Hamzeh-Mivehroud; Karim Asadpour-Zeynali
Journal:  Iran J Pharm Res       Date:  2012       Impact factor: 1.696

  2 in total

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