Literature DB >> 16906750

Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.

Rebecca M Wilson1, Samuel J Danishefsky.   

Abstract

The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.

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Year:  2006        PMID: 16906750     DOI: 10.1021/ar068018n

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN: 0001-4842            Impact factor:   22.384


  22 in total

Review 1.  Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors:  David J Newman; Gordon M Cragg
Journal:  J Nat Prod       Date:  2012-02-08       Impact factor: 4.050

Review 2.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

3.  Enantioselective total synthesis of (-)-jiadifenolide.

Authors:  Jing Xu; Lynnie Trzoss; Weng K Chang; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2011-03-11       Impact factor: 15.336

4.  Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal:  Org Lett       Date:  2011-08-03       Impact factor: 6.005

5.  An eight-step gram-scale synthesis of (-)-jiadifenolide.

Authors:  Hai-Hua Lu; Michael D Martinez; Ryan A Shenvi
Journal:  Nat Chem       Date:  2015-06-15       Impact factor: 24.427

6.  Synthesis of Neurotrophic Seco-prezizaane Sesquiterpenes (1R,10S)-2-Oxo-3,4-dehydroneomajucin, (2S)-Hydroxy-3,4-dehydroneomajucin, and (-)-Jiadifenin.

Authors:  Xiayun Cheng; Glenn C Micalizio
Journal:  J Am Chem Soc       Date:  2016-01-25       Impact factor: 15.419

7.  Total Syntheses of Lyconadins: Finding Efficiency and Diversity.

Authors:  Yang Yang; Mingji Dai
Journal:  Synlett       Date:  2014       Impact factor: 2.454

8.  Concise total syntheses of the Lycopodium alkaloids (+/-)-nankakurines A and B via luciduline.

Authors:  Xiayun Cheng; Stephen P Waters
Journal:  Org Lett       Date:  2010-01-15       Impact factor: 6.005

Review 9.  Natural products: a continuing source of novel drug leads.

Authors:  Gordon M Cragg; David J Newman
Journal:  Biochim Biophys Acta       Date:  2013-02-18

10.  Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal:  Chemistry       Date:  2013-03-22       Impact factor: 5.236

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