Literature DB >> 16905252

Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease.

Yasin Temel1, Chunyan Cao, Rinske Vlamings, Arjan Blokland, Hatice Ozen, Harry W M Steinbusch, Kimmo A Michelsen, Stephan von Hörsten, Christoph Schmitz, Veerle Visser-Vandewalle.   

Abstract

Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.

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Year:  2006        PMID： 16905252     DOI： 10.1016/j.neulet.2006.07.036

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  19 in total

Review 1.  Experimental surgical therapies for Huntington's disease.

Authors:  Jelle Demeestere; Wim Vandenberghe
Journal:  CNS Neurosci Ther       Date:  2010-12-28       Impact factor: 5.243

Review 2.  The external globus pallidus: progress and perspectives.

Authors:  Daniel J Hegeman; Ellie S Hong; Vivian M Hernández; C Savio Chan
Journal:  Eur J Neurosci       Date:  2016-03-28       Impact factor: 3.386

Review 3.  Alteration of GABAergic neurotransmission in Huntington's disease.

Authors:  Maurice Garret; Zhuowei Du; Marine Chazalon; Yoon H Cho; Jérôme Baufreton
Journal:  CNS Neurosci Ther       Date:  2018-02-21       Impact factor: 5.243

4.  External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Authors:  Noémie Ligot; Pierre Krystkowiak; Clémence Simonin; Serge Goldman; Philippe Peigneux; John Van Naemen; Michel Monclus; Simon Frédéric Lacroix; David Devos; Kathy Dujardin; Christine Delmaire; Eric Bardinet; Arnaud Delval; Marie Delliaux; Luc Defebvre; Jerome Yelnik; Serge Blond; Alain Destée; Xavier De Tiège
Journal:  J Cereb Blood Flow Metab       Date:  2010-10-20       Impact factor: 6.200

Review 5.  Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

Authors:  Bronwen Martin; Erin Golden; Alex Keselman; Matthew Stone; Mark P Mattson; Josephine M Egan; Stuart Maudsley
Journal:  Histol Histopathol       Date:  2008-02       Impact factor: 2.303

6.  Pallidal deep brain stimulation in juvenile Huntington's disease: local field potential oscillations and clinical data.

Authors:  Stefano Ferrea; Stefan J Groiss; Saskia Elben; Christian J Hartmann; Steve B Dunnett; Anne Rosser; Carsten Saft; Alfons Schnitzler; Jan Vesper; Lars Wojtecki
Journal:  J Neurol       Date:  2018-05-03       Impact factor: 4.849

7.  Deficits in discrimination after experimental frontal brain injury are mediated by motivation and can be improved by nicotinamide administration.

Authors:  Cole Vonder Haar; William R Maass; Eric A Jacobs; Michael R Hoane
Journal:  J Neurotrauma       Date:  2014-08-21       Impact factor: 5.269

8.  Altered membrane properties and firing patterns of external globus pallidus neurons in the R6/2 mouse model of Huntington's disease.

Authors:  Garnik Akopian; Joshua Barry; Carlos Cepeda; Michael S Levine
Journal:  J Neurosci Res       Date:  2016-09-12       Impact factor: 4.164

Review 9.  Beyond the rat models of human neurodegenerative disorders.

Authors:  Ondrej Bugos; Mangesh Bhide; Norbert Zilka
Journal:  Cell Mol Neurobiol       Date:  2009-03-05       Impact factor: 5.046

Review 10.  Deep brain stimulation: current challenges and future directions.

Authors:  Andres M Lozano; Nir Lipsman; Hagai Bergman; Peter Brown; Stephan Chabardes; Jin Woo Chang; Keith Matthews; Cameron C McIntyre; Thomas E Schlaepfer; Michael Schulder; Yasin Temel; Jens Volkmann; Joachim K Krauss
Journal:  Nat Rev Neurol       Date:  2019-03       Impact factor: 42.937
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