PURPOSE: To report on 32 patients who survived > or = 5 years from brain metastases treated at a single institution. METHODS AND MATERIALS: The records of 1288 patients diagnosed with brain metastases between 1973 and 1999 were reviewed. Patients were treated with whole-brain radiation therapy (WBRT), surgery, and/or stereotactic radiosurgery (SRS). Thirty-two (2.5%) > or = 5-year survivors were identified. Factors contributing to long-term survival were identified. RESULTS: Median survival was 9.3 years for > or = 5-year survivors. Seven of these patients lived > or = 10 years. Female gender was the only patient characteristic that correlated with better survival (p = 0.0369). When these patients were compared with < 5-year survivors, age < 65 years (p = 0.0044), control of the primary at diagnosis (p = 0.0052), no systemic disease (p = 0.0012), recursive partitioning analysis (RPA) Class 1 (p = 0.0002 with Class 2; p = 0.0022 with Class 3), and single brain metastasis (p = 0.0018) were associated with long-term survival in the univariate logistic regression model. In the multivariate model, RPA Class 1 compared with Class 2 (OR = 0.39, p = 0.0196), surgery (OR = 0.16, p < 0.0001), and SRS (OR = 0.41, p = 0.0188) were associated with long-term survival. CONCLUSIONS: For patients with good prognostic factors such as young age, good RPA characteristics and single metastasis, treatment with surgery or SRS offers the best chance for long-term survival.
PURPOSE: To report on 32 patients who survived > or = 5 years from brain metastases treated at a single institution. METHODS AND MATERIALS: The records of 1288 patients diagnosed with brain metastases between 1973 and 1999 were reviewed. Patients were treated with whole-brain radiation therapy (WBRT), surgery, and/or stereotactic radiosurgery (SRS). Thirty-two (2.5%) > or = 5-year survivors were identified. Factors contributing to long-term survival were identified. RESULTS: Median survival was 9.3 years for > or = 5-year survivors. Seven of these patients lived > or = 10 years. Female gender was the only patient characteristic that correlated with better survival (p = 0.0369). When these patients were compared with < 5-year survivors, age < 65 years (p = 0.0044), control of the primary at diagnosis (p = 0.0052), no systemic disease (p = 0.0012), recursive partitioning analysis (RPA) Class 1 (p = 0.0002 with Class 2; p = 0.0022 with Class 3), and single brain metastasis (p = 0.0018) were associated with long-term survival in the univariate logistic regression model. In the multivariate model, RPA Class 1 compared with Class 2 (OR = 0.39, p = 0.0196), surgery (OR = 0.16, p < 0.0001), and SRS (OR = 0.41, p = 0.0188) were associated with long-term survival. CONCLUSIONS: For patients with good prognostic factors such as young age, good RPA characteristics and single metastasis, treatment with surgery or SRS offers the best chance for long-term survival.
Authors: Kyung Rae Cho; Min Ho Lee; Doo-Sik Kong; Ho Jun Seol; Do-Hyun Nam; Jong-Mu Sun; Jin Seok Ahn; Myung-Ju Ahn; Keunchil Park; Sung Tae Kim; Do Hun Lim; Jung-Il Lee Journal: J Neurooncol Date: 2015-09-15 Impact factor: 4.130
Authors: Kaisorn L Chaichana; Shami Acharya; Mariana Flores; Olindi Wijesekera; Daniele Rigamonti; Jon D Weingart; Alessandro Olivi; Chetan Bettegowda; Gary L Gallia; Henry Brem; Michael Lim; Alfredo Quinones-Hinojosa Journal: World Neurosurg Date: 2013-09-25 Impact factor: 2.104
Authors: Rupesh Kotecha; Sally Vogel; John H Suh; Gene H Barnett; Erin S Murphy; Chandana A Reddy; Michael Parsons; Michael A Vogelbaum; Lilyana Angelov; Alireza M Mohammadi; Glen H J Stevens; David M Peereboom; Manmeet S Ahluwalia; Samuel T Chao Journal: J Neurooncol Date: 2016-07-25 Impact factor: 4.130
Authors: J Griff Kuremsky; James J Urbanic; W Jeff Petty; James F Lovato; J Daniel Bourland; Stephen B Tatter; Thomas L Ellis; Kevin P McMullen; Edward G Shaw; Michael D Chan Journal: Neurosurgery Date: 2013-10 Impact factor: 4.654