| Literature DB >> 16904757 |
Stéphanie Nguyen1, Véronique Morel, Magali Le Garff-Tavernier, Francis Bolgert, Véronique Leblond, Patrice Debré, Vincent Vieillard.
Abstract
We report a case of myasthenia gravis associated with marked expansion of an unusual CD16(+)CD56(-)2B4(+) NK subset. These atypical cells were characterized by poor cytotoxicity against CD48(+) target cells and high proliferation due to 2B4/CD48 interaction. IL18, IFN-gamma and TGF-beta levels were profoundly different in this patient than in healthy donors. Immunosuppressive treatment induced disease remission and decreased the CD16(+)CD56(-)2B4(+)NK cells count. Our data suggest that expansion of this NK subset in myasthenia gravis patients may account for the deleterious NK cell functioning that occurs in this autoimmune disease.Entities:
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Year: 2006 PMID： 16904757 DOI： 10.1016/j.jneuroim.2006.05.028
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478