Literature DB >> 16903072

Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis.

Ming-Lu Xu1, Gao Li, Dong-Cheol Moon, Chong-Soon Lee, Mi-Hee Woo, Eung Seok Lee, Yurngdong Jahng, Hyeun-Wook Chang, Seung-Ho Lee, Jong-Keun Son.   

Abstract

Four alkaloids (1-4), three quinolone alkaloids (5-7), and three flavanoid glucosides (8-10) were isolated from the fruits of Evodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds, 3, 8, 9 and 10 were isolated from this plant for the first time. Of these compounds, 1-3 and 5-7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound 8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 microM, respectively).

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Year:  2006        PMID： 16903072     DOI： 10.1007/bf02969262

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  9 in total

1.  Towards modernization of the formulation of the traditional uighur medicine herbal preparation abnormal savda munziq.

Authors:  Murat Kizaibek; Ruxandra Popescu; Sonja Prinz; Halmurat Upur; Judith Singhuber; Martin Zehl; Brigitte Kopp
Journal:  Evid Based Complement Alternat Med       Date:  2011-08-07       Impact factor: 2.629

2.  Bitterness and antibacterial activities of constituents from Evodia rutaecarpa.

Authors:  Xiaoguang Liang; Bo Li; Fei Wu; Tingzhao Li; Youjie Wang; Qiang Ma; Shuang Liang
Journal:  BMC Complement Altern Med       Date:  2017-03-29       Impact factor: 3.659

3.  Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice.

Authors:  Shun-Ting Chou; Chien-Yun Hsiang; Hsin-Yi Lo; Hui-Fen Huang; Ming-Tsung Lai; Ching-Liang Hsieh; Su-Yin Chiang; Tin-Yun Ho
Journal:  BMC Complement Altern Med       Date:  2017-02-20       Impact factor: 3.659

4.  Toxicity of Evodiae fructus on rat liver mitochondria: the role of oxidative stress and mitochondrial permeability transition.

Authors:  Qingyan Cai; Jingjing Wei; Wei Zhao; Si Shi; Yu Zhang; Renrong Wei; Yue Zhang; Weirong Li; Qi Wang
Journal:  Molecules       Date:  2014-12-16       Impact factor: 4.411

5.  Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study.

Authors:  Jingli Liu; Hui Guo; Jing Zhou; Yuwei Wang; Hao Yan; Ruyi Jin; Yuping Tang
Journal:  Int J Mol Sci       Date:  2022-09-29       Impact factor: 6.208

6.  Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.

Authors:  Lv-Cui Zhao; Jing Li; Ke Liao; Nian Luo; Qing-Qiang Shi; Zi-Qiang Feng; Di-Long Chen
Journal:  Int J Mol Sci       Date:  2015-11-16       Impact factor: 5.923

Review 7.  Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa.

Authors:  Junlin Jiang; Changping Hu
Journal:  Molecules       Date:  2009-05-18       Impact factor: 4.411

Review 8.  Progress in the studies on rutaecarpine.

Authors:  Seung Ho Lee; Jong-Keun Son; Byeong Seon Jeong; Tae-Cheon Jeong; Hyeon Wook Chang; Eung-Seok Lee; Yurngdong Jahng
Journal:  Molecules       Date:  2008-02-06       Impact factor: 4.411

9.  Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity.

Authors:  Agnes L-F Chan; Wen-Shin Chang; Li-Min Chen; Chi-Ming Lee; Chiao-En Chen; Chun-Mao Lin; Jau-Lang Hwang
Journal:  Molecules       Date:  2009-03-27       Impact factor: 4.411
  9 in total

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