Literature DB >> 16902933

Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.

Craig W Lindsley1, Zhijian Zhao, William H Leister, Julie O'Brien, Wei Lemaire, David L Williams, Tsing-Bau Chen, Raymond S L Chang, Maryann Burno, Marlene A Jacobson, Cyrille Sur, Gene G Kinney, Douglas J Pettibone, Philip R Tiller, Sheri Smith, Nancy N Tsou, Mark E Duggan, P Jeffrey Conn, George D Hartman.   

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Year:  2006        PMID： 16902933     DOI： 10.1002/cmdc.200600097

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  13 in total

Review 1.  The antipsychotic potential of muscarinic allosteric modulation.

Authors:  Thomas M Bridges; Evan P LeBois; Corey R Hopkins; Michael R Wood; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley
Journal:  Drug News Perspect       Date:  2010-05

Review 2.  Targeting glutamate synapses in schizophrenia.

Authors:  Julie R Field; Adam G Walker; P Jeffrey Conn
Journal:  Trends Mol Med       Date:  2011-09-28       Impact factor: 11.951

3.  Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone.

Authors:  Katalin Nagy; Bernadett Marko; Gabriella Zsilla; Peter Matyus; Katalin Pallagi; Geza Szabo; Zsolt Juranyi; Jozsef Barkoczy; Gyorgy Levay; Laszlo G Harsing
Journal:  Neurochem Res       Date:  2010-08-20       Impact factor: 3.996

4.  Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.

Authors:  Wesley P Blackaby; Richard T Lewis; Joanne L Thomson; Andrew S R Jennings; Simon C Goodacre; Leslie J Street; Angus M MacLeod; Andrew Pike; Suzanne Wood; Steve Thomas; Terry A Brown; Alison Smith; Gopalan Pillai; Sarah Almond; Martin R Guscott; H Donald Burns; Waisi Eng; Christine Ryan; Jacquelynn Cook; Terence G Hamill
Journal:  ACS Med Chem Lett       Date:  2010-06-25       Impact factor: 4.345

5.  Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse.

Authors:  Dorothy G Flood; Eva Zuvich; Michael J Marino; Maciej Gasior
Journal:  Psychopharmacology (Berl)       Date:  2011-02-08       Impact factor: 4.530

6.  Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.

Authors:  Carrie K Jones; Douglas J Sheffler; Richard Williams; Sataya B Jadhav; Andrew S Felts; Ryan D Morrison; Colleen M Niswender; J Scott Daniels; P Jeffrey Conn; Craig W Lindsley
Journal:  Bioorg Med Chem Lett       Date:  2014-01-13       Impact factor: 2.823

7.  Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres.

Authors:  Douglas J Sheffler; Michael T Nedelcovych; Richard Williams; Stephen C Turner; Brittany B Duerk; Megan R Robbins; Sataya B Jadhav; Colleen M Niswender; Carrie K Jones; P Jeffrey Conn; R Nathan Daniels; Craig W Lindsley
Journal:  Bioorg Med Chem Lett       Date:  2014-01-13       Impact factor: 2.823

Review 8.  Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling.

Authors:  Meredith J Noetzel; Carrie K Jones; P Jeffrey Conn
Journal:  Discov Med       Date:  2012-11       Impact factor: 2.970

9.  Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions.

Authors:  Adrienn Hanuska; Gábor Szénási; Mihaly Albert; Laszlo Koles; Agoston Varga; Andras Szabo; Peter Matyus; Laszlo G Harsing
Journal:  Neurochem Res       Date:  2015-09-12       Impact factor: 3.996

10.  Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons.

Authors:  Yvonne Schmitz; Candace Castagna; Ana Mrejeru; José E Lizardi-Ortiz; Zoe Klein; Craig W Lindsley; David Sulzer
Journal:  J Neurosci       Date:  2013-10-16       Impact factor: 6.167
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