Literature DB >> 16902859

Prenylated xanthones as potential antiplasmodial substances.

Wilawan Mahabusarakam1, Kunnika Kuaha, Prapon Wilairat, Walter C Taylor.   

Abstract

Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.

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Year:  2006        PMID： 16902859     DOI： 10.1055/s-2006-947190

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  7 in total

1.  Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.

Authors:  Yulin Ren; Susan Matthew; Daniel D Lantvit; Tran Ngoc Ninh; Heebyung Chai; James R Fuchs; Djaja D Soejarto; Esperanza J Carcache de Blanco; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2011-03-23       Impact factor: 4.050

2.  Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

Authors:  Young-Won Chin; A Douglas Kinghorn
Journal:  Mini Rev Org Chem       Date:  2008-11-01       Impact factor: 2.495

3.  The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor.

Authors:  Ryan T Larson; Jeffrey M Lorch; Julia W Pridgeon; James J Becnel; Gary G Clark; Que Lan
Journal:  J Med Entomol       Date:  2010-03       Impact factor: 2.278

4.  Proteomics analysis of antimalarial targets of Garcinia mangostana Linn.

Authors:  Wanna Chaijaroenkul; Artitiya Thiengsusuk; Kanchana Rungsihirunrat; Stephen Andrew Ward; Kesara Na-Bangchang
Journal:  Asian Pac J Trop Biomed       Date:  2014-07

Review 5.  Recent Update on Active Biological Molecules in Generating the Anticancerous Therapeutic Potential of Garcinia mangostana.

Authors:  Neha Verma; Soumya Pandit; Anil Kumar; Gulab Yadav; Shiv Kumar Giri; Dibyajit Lahiri; Zulhisyam Abdul Kari; Ram Prasad
Journal:  Appl Biochem Biotechnol       Date:  2022-07-19       Impact factor: 3.094

6.  Gartanin Compounds from Extract Ethanol Pericarp Mangosteen (Garcinia mangostana Linn.).

Authors:  R A Oetari; Hasriyani Hasriyani; Adi Prayitno; Sahidin Sahidin
Journal:  Open Access Maced J Med Sci       Date:  2019-11-14

7.  Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents.

Authors:  Xiao-Qian Chi; Cheng-Ting Zi; Hong-Mei Li; Liu Yang; Yong-Feng Lv; Jin-Yu Li; Bo Hou; Fu-Cai Ren; Jiang-Miao Hu; Jun Zhou
Journal:  RSC Adv       Date:  2018-12-12       Impact factor: 3.361
  7 in total

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