| Literature DB >> 16901981 |
Ratan D Bhardwaj1, Maurice A Curtis, Kirsty L Spalding, Bruce A Buchholz, David Fink, Thomas Björk-Eriksson, Claes Nordborg, Fred H Gage, Henrik Druid, Peter S Eriksson, Jonas Frisén.
Abstract
Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.Entities:
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Year: 2006 PMID： 16901981 PMCID： PMC1567918 DOI： 10.1073/pnas.0605177103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205