| Literature DB >> 16901824 |
Abstract
This article describes a very simple route for synthesizing a novel 5'-norcarboacyclic nucleotides. The condensation of the mesylates 17 and 18 with the natural nucleosidic bases (A,U,T,C) under standard nucleophilic substitution (K2CO3, 18-Crown-6, DMF) and deprotection afforded the target nucleotide analogues 27-34. In addition, these compounds were evaluated for their antiviral properties against various viruses.Entities:
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Year: 2006 PMID： 16901824 DOI： 10.1080/15257770600793927
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381