Literature DB >> 16901692

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.

Gerhard Puerstinger1, Jan Paeshuyse, Piet Herdewijn, Jef Rozenski, Erik De Clercq, Johan Neyts.   

Abstract

A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).

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Year:  2006        PMID： 16901692     DOI： 10.1016/j.bmcl.2006.07.081

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.

Authors:  Jan Paeshuyse; Jean-Michel Chezal; Matheus Froeyen; Pieter Leyssen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Carine Letellier; Tong Li; Harald Mittendorfer; Frank Koenen; Pierre Kerkhofs; Erik De Clercq; Piet Herdewijn; Gerhard Puerstinger; Alain Gueiffier; Olivier Chavignon; Jean-Claude Teulade; Johan Neyts
Journal:  J Virol       Date:  2007-08-08       Impact factor: 5.103

2.  Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.

Authors:  I-Hung Shih; Inge Vliegen; Betty Peng; Huiling Yang; Christy Hebner; Jan Paeshuyse; Gerhard Pürstinger; Martijn Fenaux; Yang Tian; Eric Mabery; Xiaoping Qi; Gina Bahador; Matthew Paulson; Laura S Lehman; Steven Bondy; Winston Tse; Hans Reiser; William A Lee; Uli Schmitz; Johan Neyts; Weidong Zhong
Journal:  Antimicrob Agents Chemother       Date:  2011-07-11       Impact factor: 5.191

3.  N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-methyl-benzamide.

Authors:  M Vinduvahini; Binoy Krishna Saha; H D Revanasiddappa; H C Devarajegowda
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-20

4.  N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-meth-oxy-benzene-sulfonamide.

Authors:  M Vinduvahini; S Jeyaseelan; J Shylajakumari; H D Revanasiddappa; Venkatesh B Devaru
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-12-21

5.  N-[3-(4-Fluoro-benz-yl)-2,4-dioxo-1,3-diaza-spiro-[4.5]dec-8-yl]-2-methyl-benzene-sulfonamide.

Authors:  S Jeyaseelan; M Vinduvahini; M Madaiah; Suman Bhattacharya; H D Revanasiddappa
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-12-14

Review 6.  Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives.

Authors:  Malwina Krause; Henryk Foks; Katarzyna Gobis
Journal:  Molecules       Date:  2017-03-04       Impact factor: 4.411

Review 7.  Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES).

Authors:  Erik De Clercq
Journal:  Adv Antivir Drug Des       Date:  2007-09-02

8.  Substituted imidazopyridines as potent inhibitors of HCV replication.

Authors:  Inge Vliegen; Jan Paeshuyse; Tine De Burghgraeve; Laura S Lehman; Matthew Paulson; I-Hung Shih; Eric Mabery; Nina Boddeker; Erik De Clercq; Hans Reiser; David Oare; William A Lee; Weidong Zhong; Steven Bondy; Gerhard Pürstinger; Johan Neyts
Journal:  J Hepatol       Date:  2009-02-26       Impact factor: 25.083
  8 in total

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