| Literature DB >> 16901129 |
Koen F W Hekking1, Marcel A H Moelands, Floris L van Delft, Floris P J T Rutjes.
Abstract
Novel, efficient synthetic pathways to DAH, KDO, and 2-deoxy-beta-KDO are described. Ring-closing metathesis (RCM) of highly functionalized alpha-alkoxyacrylate fragments resulted in a series of synthetically versatile oxygen heterocyclic intermediates. Further functionalization of the resulting enol ether double bond and subsequent deprotection provided the natural products in high overall yields, starting from commercially available protected sugars.Entities:
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Year: 2006 PMID： 16901129 DOI： 10.1021/jo060913x
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354