Literature DB >> 16900331

A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference.

Fang Jia1, Yi-Zheng Zhang, Chang-Mei Liu.   

Abstract

RNA interference (RNAi) might be an efficient antiviral therapy for some obstinate illness. Herein, a retrovirus-based RNAi system was developed to drive expression and delivery of Hepatitis B virus (HBV)-specific short hairpin RNA (shRNA) in HepG2 cells. The levels of HBsAg and HBeAg and that of HBV mRNA were dramatically decreased by this RNAi system in HepG2 cells transfected with Topo-HBV plasmid. Retrovirus-based RNAi thus may be useful for therapy in HBV and other viral infections and provide new clues for prophylactic vaccine development.

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Year:  2006        PMID： 16900331     DOI： 10.1007/s10529-006-9138-z

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  6 in total

1.  Transplantation of human cells in the peritoneal cavity of immunodeficient mice for rapid assays of hepatitis B virus replication.

Authors:  Mukesh Kumar; Sriram Bandi; Kang Cheng; Sanjeev Gupta
Journal:  Xenotransplantation       Date:  2011 Nov-Dec       Impact factor: 3.907

Review 2.  Gene therapeutic approaches to inhibit hepatitis B virus replication.

Authors:  Maren Gebbing; Thorsten Bergmann; Eric Schulz; Anja Ehrhardt
Journal:  World J Hepatol       Date:  2015-02-27

3.  Hepatitis B virus (HBV)-specific short hairpin RNA is capable of reducing the formation of HBV covalently closed circular (CCC) DNA but has no effect on established CCC DNA in vitro.

Authors:  Jason L Starkey; Estelle F Chiari; Harriet C Isom
Journal:  J Gen Virol       Date:  2009-01       Impact factor: 3.891

4.  Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector.

Authors:  Weiwei Wang; Hongquan Peng; Jiafu Li; Xiping Zhao; Fei Zhao; Kanghong Hu
Journal:  Virus Genes       Date:  2013-02-09       Impact factor: 2.332

5.  Hepatitis B virus inhibition in mice by lentiviral vector mediated short hairpin RNA.

Authors:  Lei Deng; Guoqiang Li; Lisen Xi; Aihong Yin; Yun Gao; Wei You; Xuehao Wang; Beicheng Sun
Journal:  BMC Gastroenterol       Date:  2009-10-06       Impact factor: 3.067

Review 6.  Inhibitors of connexin and pannexin channels as potential therapeutics.

Authors:  Joost Willebrords; Michaël Maes; Sara Crespo Yanguas; Mathieu Vinken
Journal:  Pharmacol Ther       Date:  2017-07-15       Impact factor: 12.310
  6 in total

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