Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Thrombotic arteriopathy and anticoagulation in pulmonary hypertension.

Literature DB >> 16899857

Thrombotic arteriopathy and anticoagulation in pulmonary hypertension.

Sindhu R Johnson¹, John T Granton, Sanjay Mehta.

Abstract

The role of thrombotic arteriopathy in the pathophysiology of idiopathic pulmonary arterial hypertension (IPAH) and the use of anticoagulants in the treatment of IPAH are currently controversial issues. This article reviews the evidence for a role of vascular thrombosis in the pathophysiology of IPAH. There is sufficient biological rationale to support the notion that thrombotic arteriopathy is an important pathophysiologic feature of pulmonary arterial hypertension (PAH) and that its progression materially contributes to disease progression. To date, the data from observational studies suggest that anticoagulation with warfarin is an effective intervention in patients with IPAH. Its efficacy in other causes of PAH remains speculative.

Entities: Chemical Disease Species

Mesh：

Substances：
Anticoagulants

Year: 2006 PMID： 16899857 DOI： 10.1378/chest.130.2.545

Source DB: PubMed Journal: Chest ISSN： 0012-3692 Impact factor: 9.410

Keyword Cloud
Cited

31 in total

10. Expression of the Stp1 LMW-PTP and inhibition of protein CK2 display a cooperative effect on immunophilin Fpr3 tyrosine phosphorylation and Saccharomyces cerevisiae growth.

Authors: M Marchetta; T Gamberi; S Sarno; F Magherini; G Raugei; G Camici; L A Pinna; A Modesti
Journal: Cell Mol Life Sci Date: 2004-05 Impact factor: 9.261

Thrombotic arteriopathy and anticoagulation in pulmonary hypertension.

1. Diagnostic dilemma in pulmonary arterial hypertension: idiopathic or chronic thromboembolic hypertension?

2. Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension.

3. Registry to evaluate early and long-term disease management in PAH (REVEAL).

Review 4. New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling.

5. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity.

6. Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

7. Platelet TLR4: a critical link in pulmonary arterial hypertension.

8. Is Anticoagulation Beneficial in Pulmonary Arterial Hypertension?

9. Pulmonary hypertension: diagnosis and management.

10. Expression of the Stp1 LMW-PTP and inhibition of protein CK2 display a cooperative effect on immunophilin Fpr3 tyrosine phosphorylation and Saccharomyces cerevisiae growth.