Literature DB >> 16899200

Immune dysregulation in atopic dermatitis.

Peck Y Ong1, Donald Y M Leung.   

Abstract

Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors that contribute to these abnormal responses, including key effector cells of the immune system, chemokines, defective skin barrier, genetic predisposition, and environmental triggers. Understanding these pathomechanisms may improve our current therapies for atopic dermatitis.

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Year:  2006        PMID： 16899200     DOI： 10.1007/s11882-996-0008-5

Source DB:  PubMed          Journal:  Curr Allergy Asthma Rep        ISSN： 1529-7322            Impact factor:   4.919


  50 in total

1.  T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis.

Authors:  A Trautmann; M Akdis; D Kleemann; F Altznauer; H U Simon; T Graeve; M Noll; E B Bröcker; K Blaser; C A Akdis
Journal:  J Clin Invest       Date:  2000-07       Impact factor: 14.808

2.  Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin.

Authors:  S Pastore; E Fanales-Belasio; C Albanesi; L M Chinni; A Giannetti; G Girolomoni
Journal:  J Clin Invest       Date:  1997-06-15       Impact factor: 14.808

3.  Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity.

Authors:  T Kakinuma; K Nakamura; M Wakugawa; H Mitsui; Y Tada; H Saeki; H Torii; A Asahina; N Onai; K Matsushima; K Tamaki
Journal:  J Allergy Clin Immunol       Date:  2001-03       Impact factor: 10.793

4.  IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis.

Authors:  Peter Schmid-Grendelmeier; Sabine Flückiger; Rainer Disch; Axel Trautmann; Brunello Wüthrich; Kurt Blaser; Annika Scheynius; Reto Crameri
Journal:  J Allergy Clin Immunol       Date:  2005-05       Impact factor: 10.793

5.  Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris.

Authors:  Takashi Kakinuma; Hidehisa Saeki; Yuichiro Tsunemi; Hideki Fujita; Noriko Asano; Hiroshi Mitsui; Yayoi Tada; Motoshi Wakugawa; Takahiro Watanabe; Hideshi Torii; Mayumi Komine; Akihiko Asahina; Koichiro Nakamura; Kunihiko Tamaki
Journal:  J Allergy Clin Immunol       Date:  2003-03       Impact factor: 10.793

6.  Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation.

Authors:  Takeshi Echigo; Minoru Hasegawa; Yuka Shimada; Kazuhiko Takehara; Shinichi Sato
Journal:  J Allergy Clin Immunol       Date:  2004-05       Impact factor: 10.793

7.  FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro.

Authors:  Natalija Novak; Rudolf Valenta; Barbara Bohle; Sylvia Laffer; Jörg Haberstok; Stefan Kraft; Thomas Bieber
Journal:  J Allergy Clin Immunol       Date:  2004-05       Impact factor: 10.793

8.  Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

Authors:  Vassili Soumelis; Pedro A Reche; Holger Kanzler; Wei Yuan; Gina Edward; Bernhart Homey; Michel Gilliet; Steve Ho; Svetlana Antonenko; Annti Lauerma; Kathleen Smith; Daniel Gorman; Sandra Zurawski; Jon Abrams; Satish Menon; Terri McClanahan; Rene de Waal-Malefyt Rd; Fernando Bazan; Robert A Kastelein; Yong-Jun Liu
Journal:  Nat Immunol       Date:  2002-06-10       Impact factor: 25.606

Review 9.  New insights into atopic dermatitis.

Authors:  Donald Y M Leung; Mark Boguniewicz; Michael D Howell; Ichiro Nomura; Qutayba A Hamid
Journal:  J Clin Invest       Date:  2004-03       Impact factor: 14.808

Review 10.  Chemokine networks in atopic dermatitis: traffic signals of disease.

Authors:  Andor Pivarcsi; Bernhard Homey
Journal:  Curr Allergy Asthma Rep       Date:  2005-07       Impact factor: 4.919
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  39 in total

Review 1.  Eczema in early life: genetics, the skin barrier, and lessons learned from birth cohort studies.

Authors:  Jocelyn M Biagini Myers; Gurjit K Khurana Hershey
Journal:  J Pediatr       Date:  2010-08-24       Impact factor: 4.406

2.  Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice.

Authors:  Nobuaki Mizutani; Chutha Sae-Wong; Sureeporn Kangsanant; Takeshi Nabe; Shin Yoshino
Journal:  Immunology       Date:  2015-09-24       Impact factor: 7.397

3.  Association of staphylococcal superantigen-specific immunoglobulin e with mild and moderate atopic dermatitis.

Authors:  Peck Y Ong; Mona Patel; Ronald M Ferdman; Theresa Dunaway; Joseph A Church
Journal:  J Pediatr       Date:  2008-07-14       Impact factor: 4.406

Review 4.  Galectin-3 and the skin.

Authors:  Larissa Larsen; Huan-Yuan Chen; Jun Saegusa; Fu-Tong Liu
Journal:  J Dermatol Sci       Date:  2011-08-11       Impact factor: 4.563

5.  Epidermal tight junctions in health and disease.

Authors:  J M Brandner; M Zorn-Kruppa; T Yoshida; I Moll; L A Beck; A De Benedetto
Journal:  Tissue Barriers       Date:  2015-04-03

6.  Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection.

Authors:  Hitokazu Esaki; David A Ewald; Benjamin Ungar; Mariya Rozenblit; Xiuzhong Zheng; Hui Xu; Yeriel D Estrada; Xiangyu Peng; Hiroshi Mitsui; Thomas Litman; Mayte Suárez-Fariñas; James G Krueger; Emma Guttman-Yassky
Journal:  J Allergy Clin Immunol       Date:  2015-01       Impact factor: 10.793

7.  Atopic dermatitis.

Authors:  Thomas Bieber
Journal:  Ann Dermatol       Date:  2010-05-17       Impact factor: 1.444

Review 8.  Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.

Authors:  Julia K Gittler; James G Krueger; Emma Guttman-Yassky
Journal:  J Allergy Clin Immunol       Date:  2012-08-28       Impact factor: 10.793

9.  Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.

Authors:  Emma Guttman-Yassky; Michelle A Lowes; Judilyn Fuentes-Duculan; Lisa C Zaba; Irma Cardinale; Kristine E Nograles; Artemis Khatcherian; Inna Novitskaya; John A Carucci; Reuven Bergman; James G Krueger
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

10.  Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice.

Authors:  Karina P Debes; Nathalie A Evdina; Ann Laigaard; Julie M Larsen; Line F Zachariassen; Camilla H F Hansen; Axel K Hansen
Journal:  Comp Med       Date:  2019-11-19       Impact factor: 0.982
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