| Literature DB >> 16898569 |
Ram Weiss, Sara E Taksali, Sonia Caprio.
Abstract
Type 2 diabetes is emerging as a significant health problem in children and adolescents. The disease usually develops in obese insulin-resistant youth with a typical pattern of lipid partitioning characterized by increased lipid deposition in myocytes, the visceral compartment, and the liver. Unfavorable adipocytokine profiles, together with a state of low-grade inflammation, create an additional metabolic burden tightly coupled to other components of the metabolic syndrome. Insufficient beta-cell compensation promotes altered glucose metabolism.Entities:
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Year: 2006 PMID: 16898569 DOI: 10.1007/s11892-006-0032-9
Source DB: PubMed Journal: Curr Diab Rep ISSN: 1534-4827 Impact factor: 4.810