| Literature DB >> 16898414 |
Bruce S Ross1, Mingming Han, Vasulinga T Ravikumar.
Abstract
An efficient process to synthesize 5'-O-dimethoxytrityl-N4-benzoyl-5-methyl-2'-deoxycytidine in high yield and quality is described. Final benzoylation was improved by developing a method to selectively hydrolyze benzoyl ester impurities. This inexpensive approach was scaled up to multikilogram quantities for routine use in oligonucleotide therapeutics.Entities:
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Year: 2006 PMID： 16898414 DOI： 10.1080/15257770600726059
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381