Literature DB >> 1689762

Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.

W R Weiss1, S Mellouk, R A Houghten, M Sedegah, S Kumar, M F Good, J A Berzofsky, L H Miller, S L Hoffman.   

Abstract

Irradiated malaria sporozoites can induce CD8+ T cells that are required for protection against infection. However, the parasite antigens targeted by this immune response are unknown. We have discovered a 16-amino acid epitope from the Plasmodium yoelii circumsporozoite (CS) protein that is recognized by cytotoxic T cells from immune mice. Lymphocytes stimulated with this peptide can kill P. yoelii liver stage parasites in vitro in an MHC-restricted, antigen-specific manner. Thus, epitopes from the CS protein are presented on the surface of infected hepatocytes and can be targets for T cells, even though intact CS protein has not been detected on the surface of the infected hepatocyte. A vaccine that induced CTL to parasite antigens might protect humans against malaria by eliminating liver stage parasites.

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Year:  1990        PMID： 1689762      PMCID： PMC2187765          DOI： 10.1084/jem.171.3.763

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  30 in total

1.  Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin.

Authors:  T J Braciale; M T Sweetser; L A Morrison; D J Kittlesen; V L Braciale
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

2.  CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

Authors:  W R Weiss; M Sedegah; R L Beaudoin; L H Miller; M F Good
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

3.  The fate of the circumsporozoite antigens during the exoerythrocytic stage of Plasmodium berghei.

Authors:  A Suhrbier; A J Hamilton; J Nicholas; R E Sinden
Journal:  Eur J Cell Biol       Date:  1988-04       Impact factor: 4.492

4.  Immunization of man against sporozite-induced falciparum malaria.

Authors:  D F Clyde; H Most; V C McCarthy; J P Vanderberg
Journal:  Am J Med Sci       Date:  1973-09       Impact factor: 2.378

5.  IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

Authors:  M Sarmiento; A L Glasebrook; F W Fitch
Journal:  J Immunol       Date:  1980-12       Impact factor: 5.422

6.  Structural model of HLA-DR1 restricted T cell antigen recognition.

Authors:  J B Rothbard; R I Lechler; K Howland; V Bal; D D Eckels; R Sekaly; E O Long; W R Taylor; J R Lamb
Journal:  Cell       Date:  1988-02-26       Impact factor: 41.582

7.  Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites.

Authors:  L Schofield; J Villaquiran; A Ferreira; H Schellekens; R Nussenzweig; V Nussenzweig
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

8.  Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei.

Authors:  R S Nussenzweig; J Vanderberg; H Most; C Orton
Journal:  Nature       Date:  1967-10-14       Impact factor: 49.962

9.  Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines.

Authors:  A A Lal; V F de la Cruz; J A Welsh; Y Charoenvit; W L Maloy; T F McCutchan
Journal:  J Biol Chem       Date:  1987-03-05       Impact factor: 5.157

10.  Serological reactivity of in vitro cultured exoerythrocytic stages of Plasmodium berghei in indirect immunofluorescent or immunoperoxidase antibody tests.

Authors:  M R Hollingdale; P Leland; J L Leef; M F Leef; R L Beaudoin
Journal:  Am J Trop Med Hyg       Date:  1983-01       Impact factor: 2.345
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  63 in total

1.  HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls.

Authors:  Kirsten E Lyke; Robin B Burges; Yacouba Cissoko; Lansana Sangare; Abdoulaye Kone; Modibo Dao; Issa Diarra; Marcelo A Fernández-Vina; Christopher V Plowe; Ogobara K Doumbo; Marcelo B Sztein
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Geographically restricted heterogeneity of the Plasmodium falciparum circumsporozoite protein: relevance for vaccine development.

Authors:  D L Doolan; A J Saul; M F Good
Journal:  Infect Immun       Date:  1992-02       Impact factor: 3.441

3.  Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids.

Authors:  R Wang; D L Doolan; Y Charoenvit; R C Hedstrom; M J Gardner; P Hobart; J Tine; M Sedegah; V Fallarme; J B Sacci; M Kaur; D M Klinman; S L Hoffman; W R Weiss
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

4.  Early hepatic stages of Plasmodium berghei: release of circumsporozoite protein and host cellular inflammatory response.

Authors:  Z M Khan; C Ng; J P Vanderberg
Journal:  Infect Immun       Date:  1992-01       Impact factor: 3.441

Review 5.  The development of a multivalent DNA vaccine for malaria.

Authors:  R C Hedstrom; D L Doolan; R Wang; M J Gardner; A Kumar; M Sedegah; R A Gramzinski; J B Sacci; Y Charoenvit; W R Weiss; M Margalith; J A Norman; P Hobart; S L Hoffman
Journal:  Springer Semin Immunopathol       Date:  1997

Review 6.  Class I HLA-restricted cytotoxic T lymphocyte responses against malaria--elucidation on the basis of HLA peptide binding motifs.

Authors:  D L Doolan; B Wizel; S L Hoffman
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

7.  Advances and challenges in malaria vaccine development.

Authors:  Ruobing Wang; Joseph D Smith; Stefan H I Kappe
Journal:  Expert Rev Mol Med       Date:  2009-12-16       Impact factor: 5.600

8.  Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.

Authors:  S Li; M Rodrigues; D Rodriguez; J R Rodriguez; M Esteban; P Palese; R S Nussenzweig; F Zavala
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

9.  The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial.

Authors:  Régine Audran; Floriana Lurati-Ruiz; Blaise Genton; Hildur E Blythman; Opokua Ofori-Anyinam; Christophe Reymond; Giampietro Corradin; François Spertini
Journal:  PLoS One       Date:  2009-10-02       Impact factor: 3.240

10.  A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites.

Authors:  Marjorie Mauduit; Anne Charlotte Grüner; Rita Tewari; Nadya Depinay; Michèle Kayibanda; Jean-Marc Chavatte; Jean-François Franetich; Andrea Crisanti; Dominique Mazier; Georges Snounou; Laurent Rénia
Journal:  PLoS One       Date:  2009-11-05       Impact factor: 3.240
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