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Literature DB >> 16897403

An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism.

F Giannotti¹, F Cortesi, A Cerquiglini, P Bernabei.

Abstract

Long-term effectiveness of controlled-release melatonin in 25 children, aged 2.6-9.6 years with autism without other coexistent pathologies was evaluated openly. Sleep patterns were studied using Children's Sleep Habits Questionnaire (CSHQ) and sleep diaries at baseline, after 1-3-6 months melatonin treatment and 1 month after discontinuation. Sleep diary and CSHQ showed a more problematic sleep in autistic children compared with controls. During treatment sleep patterns of all children improved. After discontinuation 16 children returned to pre-treatment score, readministration of melatonin was again effective. Treatment gains were maintained at 12 and 24-month follow-ups. No adverse side effects were reported. In conclusion, controlled-release melatonin may provide an effective and well-tolerated treatment for autistic children with chronic sleep disorders.

Entities: Chemical Disease Species

Mesh：

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Year: 2006 PMID： 16897403 DOI： 10.1007/s10803-006-0116-z

Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257

45 in total

1. A melatonin preparation with a pulsatile liberation pattern: a new form of melatonin in replacement therapy.

Authors: A Hoffmann; K Farker; M Dittgen; H Hoffmann
Journal: Biol Signals Recept Date: 1999 Jan-Apr

2. Sleep problems in autism: prevalence, cause, and intervention.

Authors: A L Richdale
Journal: Dev Med Child Neurol Date: 1999-01 Impact factor: 5.449

3. Developmental regression in autism: maternal perception.

Authors: M Davidovitch; L Glick; G Holtzman; E Tirosh; M P Safir
Journal: J Autism Dev Disord Date: 2000-04

4. Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism.

Authors: I Nir; D Meir; N Zilber; H Knobler; J Hadjez; Y Lerner
Journal: J Autism Dev Disord Date: 1995-12

Review 5. Melatonin: a sleep-promoting hormone.

Authors: I V Zhdanova; H J Lynch; R J Wurtman
Journal: Sleep Date: 1997-10 Impact factor: 5.849

6. The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children.

Authors: J A Owens; A Spirito; M McGuinn
Journal: Sleep Date: 2000-12-15 Impact factor: 5.849

7. Validity and reliability of the Childhood Autism Rating Scale with autistic adolescents.

Authors: D G Garfin; D McCallon; R Cox
Journal: J Autism Dev Disord Date: 1988-09

8. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS).

Authors: E Schopler; R J Reichler; R F DeVellis; K Daly
Journal: J Autism Dev Disord Date: 1980-03

9. Sleep patterns of children with pervasive developmental disorders.

Authors: Ryan D Honomichl; Beth L Goodlin-Jones; Melissa Burnham; Erika Gaylor; Thomas F Anders
Journal: J Autism Dev Disord Date: 2002-12

Review 10. Epidemiological surveys of autism and other pervasive developmental disorders: an update.

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Journal: J Autism Dev Disord Date: 2003-08

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9. The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome.

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10. Complementary alternative medicine for children with autism: a physician survey.

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