Literature DB >> 16896875

Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy.

F Malek1, P Krueger, Z N Hatmi, A A Malayeri, H Faezipour, R J O'Donnell.   

Abstract

Giant cell tumour (GCT) is a benign, but aggressive, primary tumour of the bone. The recurrence rate after surgical treatment has been reported to be as high as 50%. Many surgical techniques have been employed in the treatment of this tumour. More aggressive interventions, such as en bloc resection and bulk allograft or prosthetic reconstruction, are generally understood to be associated with lower rates of local recurrence. However, because of lessened morbidity, intralesional techniques have come to be favoured for this condition. In addition to curettage, various adjuvant procedures and packing materials have been advocated in order to control and reconstruct long bone defects secondary to this neoplasm. We report our experience with 40 long bone GCT patients treated with curettage, burring, bone grafting and no adjuvants between 1997 and 2002. There was a local recurrence rate of 32.5%, with most recurrences noted within the first 30 months after surgery. Minor complications were found in 18% of patients. The risk of local recurrence in this study is acceptable (within the range that has been historically reported for curettage and bone grafting). In cases where more resources are available, the addition of adjuvant therapies, as noted in the recent literature, may be beneficial. The results of this study should be considered when designing multicenteric studies in the future.

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Year:  2006        PMID: 16896875      PMCID: PMC3172751          DOI: 10.1007/s00264-006-0146-3

Source DB:  PubMed          Journal:  Int Orthop        ISSN: 0341-2695            Impact factor:   3.075


  19 in total

1.  Customized treatment algorithm for giant cell tumor of bone: report of a series.

Authors:  William G Ward; Galaxy Li
Journal:  Clin Orthop Relat Res       Date:  2002-04       Impact factor: 4.176

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Journal:  J Bone Joint Surg Am       Date:  1970-06       Impact factor: 5.284

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Journal:  J Bone Joint Surg Am       Date:  1993-11       Impact factor: 5.284

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Journal:  Clin Orthop Relat Res       Date:  2002-04       Impact factor: 4.176

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Journal:  J Bone Joint Surg Am       Date:  1982-06       Impact factor: 5.284

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Journal:  J Bone Joint Surg Am       Date:  1987-01       Impact factor: 5.284

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Authors:  W F Enneking
Journal:  Clin Orthop Relat Res       Date:  1986-03       Impact factor: 4.176

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  37 in total

1.  Partial wrist arthrodesis versus arthroplasty for distal radius giant cell tumours.

Authors:  Zhongsheng Zhu; Chunlin Zhang; Shichang Zhao; Yang Dong; Bingfang Zeng
Journal:  Int Orthop       Date:  2013-08-08       Impact factor: 3.075

2.  Reconstruction of distal radius by fibula following excision of grade III giant cell tumour: follow-up of 18 cases.

Authors:  Sun Peng-Fei; Jia Yu-Hua
Journal:  Int Orthop       Date:  2010-02-14       Impact factor: 3.075

3.  Clinical effects of three surgical approaches for a giant cell tumor of the distal radius and ulna.

Authors:  Jing Zhang; Yi Li; Dongqi Li; Junfeng Xia; Su Li; Shunling Yu; Yedan Liao; Xiaojuan Li; Huilin Li; Zuozhang Yang
Journal:  Mol Clin Oncol       Date:  2016-09-21

4.  Conservative surgery in the treatment of giant cell tumor of the sacrum: 35 years' experience.

Authors:  Stepan V Domovitov; Chandhanarat Chandhanayingyong; Patrick J Boland; David G McKeown; John H Healey
Journal:  J Neurosurg Spine       Date:  2015-10-30

Review 5.  Giant cell tumour of bone: a new evaluating system is necessary.

Authors:  Han Wang; Ningjun Wan; Yongcheng Hu
Journal:  Int Orthop       Date:  2012-10-05       Impact factor: 3.075

6.  Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine.

Authors:  Yifei Ma; Jialin Li; Jun Pan; Wangjun Yan; Quan Huang; Tielong Liu; Xinghai Yang; Cheng Yang; Wei Xu; Haifeng Wei; Jianru Xiao
Journal:  Eur Spine J       Date:  2016-03-17       Impact factor: 3.134

7.  Analysis of long-term outcome of image-guided volumetric modulated arc therapy (VMAT) for primary malignant tumor of the cervical spine.

Authors:  Ping Jiang; Xile Zhang; Weijuan Jiang; Na Meng; Abudureyimujiang Aili; Junjie Wang
Journal:  Cancer Biol Ther       Date:  2020-04-16       Impact factor: 4.742

Review 8.  The impact of curettage technique on local control in giant cell tumour of bone.

Authors:  Gennady N Machak; Andrey I Snetkov
Journal:  Int Orthop       Date:  2020-10-22       Impact factor: 3.075

9.  Treatment and outcome of giant cell tumors of the pelvis.

Authors:  Maurice Balke; Arne Streitbuerger; Tymoteusz Budny; Marcel Henrichs; Georg Gosheger; Jendrik Hardes
Journal:  Acta Orthop       Date:  2009-10       Impact factor: 3.717

10.  Bone defects following curettage do not necessarily need augmentation.

Authors:  Martti Hirn; Uday de Silva; Sujith Sidharthan; Robert J Grimer; Adesegun Abudu; Roger M Tillman; Simon R Carter
Journal:  Acta Orthop       Date:  2009-02       Impact factor: 3.717

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