Literature DB >> 16896725

Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia.

F Markos1, H M Snow.   

Abstract

Our aim was to confirm the role of postganglionic vagal fibres and vasoactive intestinal polypeptide (VIP) in mediating the vagal tachycardia in anaesthetised dogs. Vagal postganglionic stimulation after atenolol (1 mg/kg) and hexamethonium (10 mg/kg) caused a bradycardia (40 beats/min, n = 2), after atropine (0.5 mg/kg i.v.) the resulting tachycardia (37 beats/min) was attenuated by VIP receptor antagonism with VIP (6-28) (100 mug i.c.) by approximately 50%. VIP release from vagal postganglionic fibres mediates the vagal tachycardia.

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Year:  2006        PMID： 16896725     DOI： 10.1007/s00421-006-0270-1

Source DB:  PubMed          Journal:  Eur J Appl Physiol        ISSN： 1439-6319            Impact factor:   3.078


  7 in total

1.  Epicardial sites for vagal mediation of sinoatrial function.

Authors:  J D Mick; R D Wurster; M Duff; M Weber; W C Randall; D C Randall
Journal:  Am J Physiol       Date:  1992-05

2.  The potentiation of sinus arrhythmia by vasoactive intestinal polypeptide (VIP) in the anaesthetized dog.

Authors:  F Markos; H M Snow
Journal:  Neuropeptides       Date:  2001 Oct-Dec       Impact factor: 3.286

Review 3.  Cardioprotective role of the VIP signaling system.

Authors:  Magdalena Chottová Dvoráková
Journal:  Drug News Perspect       Date:  2005 Jul-Aug

4.  Inhibition of neuronal nitric oxide reduces heart rate variability in the anaesthetised dog.

Authors:  F Markos; H M Snow; C Kidd; K Conlon
Journal:  Exp Physiol       Date:  2001-09       Impact factor: 2.969

5.  An investigation into the physiological relevance of the vagal tachycardia in the anaesthetized dog.

Authors:  F Markos; H M Snow
Journal:  Acta Physiol (Oxf)       Date:  2006-03       Impact factor: 6.311

6.  An evaluation of the efficacy of vasoactive intestinal polypeptide antagonists in vivo in the anaesthetized dog.

Authors:  F Markos; B A Hennessy; M Fitzpatrick; J O'Sullivan; H M Snow
Journal:  Pharmacology       Date:  2002-12       Impact factor: 2.547

7.  Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.

Authors:  M R Hill; D W Wallick; L R Mongeon; P J Martin; M N Levy
Journal:  Am J Physiol       Date:  1995-10
  7 in total
  1 in total

1.  Decreased adrenoceptor stimulation in heart failure rats reduces NGF expression by cardiac parasympathetic neurons.

Authors:  Wohaib Hasan; Peter G Smith
Journal:  Auton Neurosci       Date:  2013-12-04       Impact factor: 3.145
  1 in total

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