Literature DB >> 16896543

Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.

Martine Schmitt1, João X de Araújo-Júnior, Said Oumouch, Jean-Jacques Bourguignon.   

Abstract

An efficient method for preparation of 4,6 or 5,6 disubstituted 3-aminopyridazines was easily carried out starting from easily available 4-bromo-pyridazine-3,6-dione, and using combination of both amination and Pd(0) cross-coupling reactions under microwave irradiation.

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Year:  2006        PMID： 16896543     DOI： 10.1007/s11030-006-9020-x

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  6 in total

1.  Design of small-sized libraries by combinatorial assembly of linkers and functional groups to a given scaffold: application to the structure-based optimization of a phosphodiesterase 4 inhibitor.

Authors:  Mireille Krier; João X de Araújo-Júnior; Martine Schmitt; Jérôme Duranton; Hélène Justiano-Basaran; Claire Lugnier; Jean-Jacques Bourguignon; Didier Rognan
Journal:  J Med Chem       Date:  2005-06-02       Impact factor: 7.446

2.  5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.

Authors:  Y Rival; R Hoffmann; B Didier; V Rybaltchenko; J J Bourguignon; C G Wermuth
Journal:  J Med Chem       Date:  1998-01-29       Impact factor: 7.446

3.  Aminopyridazines as acetylcholinesterase inhibitors.

Authors:  J M Contreras; Y M Rival; S Chayer; J J Bourguignon; C G Wermuth
Journal:  J Med Chem       Date:  1999-02-25       Impact factor: 7.446

4.  Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists.

Authors:  C G Wermuth; J J Bourguignon; G Schlewer; J P Gies; A Schoenfelder; A Melikian; M J Bouchet; D Chantreux; J C Molimard; M Heaulme
Journal:  J Med Chem       Date:  1987-02       Impact factor: 7.446

5.  Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines.

Authors:  J D Albright; D B Moran; W B Wright; J B Collins; B Beer; A S Lippa; E N Greenblatt
Journal:  J Med Chem       Date:  1981-05       Impact factor: 7.446

6.  An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

Authors:  Anastasia V Velentza; Mark S Wainwright; Magdalena Zasadzki; Salida Mirzoeva; Andrew M Schumacher; Jacques Haiech; Pamela J Focia; Martin Egli; D Martin Watterson
Journal:  Bioorg Med Chem Lett       Date:  2003-10-20       Impact factor: 2.823
  6 in total
  2 in total

1.  Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.

Authors:  Joshua Almond-Thynne; David C Blakemore; David C Pryde; Alan C Spivey
Journal:  Chem Sci       Date:  2016-08-09       Impact factor: 9.825

2.  Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues.

Authors:  Mohamed Elagawany; Martine Schmitt; Adel Ghiaty; A Sh El-Etrawy; Mohamed A Ibrahim; Frederic Bihel; Aline Borba Sbardelotto; Claudia Pessoa; Tam Luong Nguyen; Ernest Hamel; Jean Jacques Bourguignon
Journal:  Anticancer Agents Med Chem       Date:  2013-09       Impact factor: 2.505
  2 in total

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