Literature DB >> 16896351

The anaphase promoting complex/cyclosome: a machine designed to destroy.

Jan-Michael Peters1.   

Abstract

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

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Year:  2006        PMID： 16896351     DOI： 10.1038/nrm1988

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  610 in total

1.  Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Susan L Morris-Natschke; Chen-Fang Wei; Ting-Chen Shen; Hui-Yi Lin; Mei-Hua Hsu; Li-Chen Chou; Yu Zhao; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

2.  GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.

Authors:  Eriko Iwata; Saki Ikeda; Sachihiro Matsunaga; Mariko Kurata; Yasushi Yoshioka; Marie-Claire Criqui; Pascal Genschik; Masaki Ito
Journal:  Plant Cell       Date:  2011-12-13       Impact factor: 11.277

3.  The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

Authors:  Hideaki Naoe; Kimi Araki; Osamu Nagano; Yusuke Kobayashi; Jo Ishizawa; Tatsuyuki Chiyoda; Takatsune Shimizu; Ken-ichi Yamamura; Yutaka Sasaki; Hideyuki Saya; Shinji Kuninaka
Journal:  Mol Cell Biol       Date:  2010-06-07       Impact factor: 4.272

4.  The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.

Authors:  Jennifer R Kowalski; Hitesh Dube; Denis Touroutine; Kristen M Rush; Patricia R Goodwin; Marc Carozza; Zachary Didier; Michael M Francis; Peter Juo
Journal:  Mol Cell Neurosci       Date:  2013-12-07       Impact factor: 4.314

Review 5.  Orchestrating nuclear envelope disassembly and reassembly during mitosis.

Authors:  Stephan Güttinger; Eva Laurell; Ulrike Kutay
Journal:  Nat Rev Mol Cell Biol       Date:  2009-03       Impact factor: 94.444

6.  Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Authors:  Seung Baek Lee; Jung Jin Kim; Hyun-Ja Nam; Bowen Gao; Ping Yin; Bo Qin; Sang-Yeop Yi; Hyoungjun Ham; Debra Evans; Sun-Hyun Kim; Jun Zhang; Min Deng; Tongzheng Liu; Haoxing Zhang; Daniel D Billadeau; Liewei Wang; Emilie Giaime; Jie Shen; Yuan-Ping Pang; Jin Jen; Jan M van Deursen; Zhenkun Lou
Journal:  Mol Cell       Date:  2015-09-17       Impact factor: 17.970

7.  Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.

Authors:  Maiko Okada; Fumiaki Ohtake; Hiroyuki Nishikawa; Wenwen Wu; Yasushi Saeki; Keiji Takana; Tomohiko Ohta
Journal:  Mol Endocrinol       Date:  2015-09-21

Review 8.  Cell cycle, CDKs and cancer: a changing paradigm.

Authors:  Marcos Malumbres; Mariano Barbacid
Journal:  Nat Rev Cancer       Date:  2009-03       Impact factor: 60.716

9.  Cyclin B2 and p53 control proper timing of centrosome separation.

Authors:  Hyun-Ja Nam; Jan M van Deursen
Journal:  Nat Cell Biol       Date:  2014-04-28       Impact factor: 28.824

10.  C-terminal region of Mad2 plays an important role during mitotic spindle checkpoint in fission yeast Schizosaccharomyces pombe.

Authors:  Gaurav Kumar Singh; Sharanbasappa Shrimant Karade; Rajeev Ranjan; Nafees Ahamad; Shakil Ahmed
Journal:  Mol Biol Rep       Date:  2016-09-23       Impact factor: 2.316
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