Literature DB >> 16896227

Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulans.

Márcia Eliana da Silva Ferreira1, Marcela Savoldi, Pierina Sueli Bonato, Maria Helena S Goldman, Gustavo H Goldman.   

Abstract

Mutations in the human HPD gene (encoding 4-hydroxyphenylpyruvic acid dioxygenase) cause hereditary tyrosinemia type 3 (HT3). We deleted the Aspergillus nidulans homologue (hpdA). We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype.

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Year:  2006        PMID： 16896227      PMCID： PMC1539140          DOI： 10.1128/EC.00160-06

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  19 in total

1.  A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans.

Authors:  M K Chaveroche; J M Ghigo; C d'Enfert
Journal:  Nucleic Acids Res       Date:  2000-11-15       Impact factor: 16.971

2.  PCR-mediated generation of a gene disruption construct without the use of DNA ligase and plasmid vectors.

Authors:  Hidekazu Kuwayama; Shinji Obara; Takahiro Morio; Mariko Katoh; Hideko Urushihara; Yoshimasa Tanaka
Journal:  Nucleic Acids Res       Date:  2002-01-15       Impact factor: 16.971

Review 3.  Tyrosinemia: a review.

Authors:  P A Russo; G A Mitchell; R M Tanguay
Journal:  Pediatr Dev Pathol       Date:  2001 May-Jun

Review 4.  A fungal perspective on human inborn errors of metabolism: alkaptonuria and beyond.

Authors:  M A Peñalva
Journal:  Fungal Genet Biol       Date:  2001-10       Impact factor: 3.495

5.  Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay.

Authors:  Camile Pizeta Semighini; Mozart Marins; Maria Helena S Goldman; Gustavo Henrique Goldman
Journal:  Appl Environ Microbiol       Date:  2002-03       Impact factor: 4.792

Review 6.  4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target.

Authors:  Ding-Yah Yang
Journal:  Drug News Perspect       Date:  2003-10

Review 7.  Animal models reveal pathophysiologies of tyrosinemias.

Authors:  Fumio Endo; Yasuhiko Tanaka; Kaede Tomoeda; Akito Tanoue; Gozoh Tsujimoto; Kimitoshi Nakamura
Journal:  J Nutr       Date:  2003-06       Impact factor: 4.798

8.  Fungal metabolic model for type I 3-methylglutaconic aciduria.

Authors:  José M Rodríguez; Pedro Ruíz-Sala; Magdalena Ugarte; Miguel A Peñalva
Journal:  J Biol Chem       Date:  2004-06-04       Impact factor: 5.157

9.  Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency.

Authors:  José M Rodríguez; Pedro Ruíz-Sala; Magdalena Ugarte; Miguel A Peñalva
Journal:  J Biol Chem       Date:  2003-11-11       Impact factor: 5.157

10.  Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Authors:  James E Galagan; Sarah E Calvo; Christina Cuomo; Li-Jun Ma; Jennifer R Wortman; Serafim Batzoglou; Su-In Lee; Meray Baştürkmen; Christina C Spevak; John Clutterbuck; Vladimir Kapitonov; Jerzy Jurka; Claudio Scazzocchio; Mark Farman; Jonathan Butler; Seth Purcell; Steve Harris; Gerhard H Braus; Oliver Draht; Silke Busch; Christophe D'Enfert; Christiane Bouchier; Gustavo H Goldman; Deborah Bell-Pedersen; Sam Griffiths-Jones; John H Doonan; Jaehyuk Yu; Kay Vienken; Arnab Pain; Michael Freitag; Eric U Selker; David B Archer; Miguel A Peñalva; Berl R Oakley; Michelle Momany; Toshihiro Tanaka; Toshitaka Kumagai; Kiyoshi Asai; Masayuki Machida; William C Nierman; David W Denning; Mark Caddick; Michael Hynes; Mathieu Paoletti; Reinhard Fischer; Bruce Miller; Paul Dyer; Matthew S Sachs; Stephen A Osmani; Bruce W Birren
Journal:  Nature       Date:  2005-12-22       Impact factor: 49.962
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  4 in total

1.  Transcriptome analysis of Stagonospora nodorum: gene models, effectors, metabolism and pantothenate dispensability.

Authors:  Simon V S Ipcho; James K Hane; Eva A Antoni; Dag Ahren; Bernard Henrissat; Timothy L Friesen; Peter S Solomon; Richard P Oliver
Journal:  Mol Plant Pathol       Date:  2011-12-06       Impact factor: 5.663

2.  Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae.

Authors:  Yi Wang; Ziyi Wang; Sauban Musa Jibril; Mian Wei; Xin Pu; Chao Yang; Chan Ma; Qi Wu; Lina Liu; Yiji Quan; Chengyun Li
Journal:  Int J Mol Sci       Date:  2022-06-27       Impact factor: 6.208

3.  Intracellular growth is dependent on tyrosine catabolism in the dimorphic fungal pathogen Penicillium marneffei.

Authors:  Kylie J Boyce; Alisha McLauchlan; Lena Schreider; Alex Andrianopoulos
Journal:  PLoS Pathog       Date:  2015-03-26       Impact factor: 6.823

4.  Metabolic Pathway Profiling in Intracellular and Extracellular Environments of Streptococcus thermophilus During pH-Controlled Batch Fermentations.

Authors:  Yali Qiao; Gefei Liu; Xuepeng Lv; Xuejing Fan; Yanjiao Zhang; Li Meng; Mingzhi Ai; Zhen Feng
Journal:  Front Microbiol       Date:  2020-01-21       Impact factor: 5.640
  4 in total

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