Literature DB >> 16895813

Clinical heterogeneity was a common problem in Cochrane reviews of physiotherapy and occupational therapy.

Cornelia H M van den Ende1, Esther M J Steultjens, Lex M Bouter, Joost Dekker.   

Abstract

BACKGROUND AND
OBJECTIVE: To identify the strategies used to deal with the clinical heterogeneity of interventions and multiple outcome measures used in Cochrane reviews on physiotherapy and occupational therapy.
METHODS: A search for systematic reviews on physiotherapy and occupational therapy in the Cochrane Library was performed. Data on the method of categorization of interventions, on measures, and on the method of data synthesis were systematically extracted.
RESULTS: 52 reviews were identified. In 22 (42%) reviews only one index intervention was evaluated, in the other 30 reviews index interventions were categorized. A large diversity in the number and type of outcome measures was found (median 6.5, range 1-23). In 48% of the reviews one or more primary outcome measures were defined. In 52% of the reviews no quantitative data synthesis was performed, whereas five different methods for qualitative data synthesis were applied in 11 reviews.
CONCLUSIONS: Limitation to a few outcome measures and explicit procedures for the categorization of interventions might increase the transparency and reproducibility of systematic reviews on physiotherapy and occupational therapy. Qualitative data synthesis is not often applied, although it is a useful tool to summarize results if a quantitative synthesis is not appropriate. International consensus on a method for qualitative synthesis is clearly needed.

Mesh:

Year:  2006        PMID: 16895813     DOI: 10.1016/j.jclinepi.2005.12.014

Source DB:  PubMed          Journal:  J Clin Epidemiol        ISSN: 0895-4356            Impact factor:   6.437


  5 in total

Review 1.  Organization of Rehabilitation Services in Randomized Controlled Trials: Which Factors Influence Functional Outcome? A Systematic Review.

Authors:  Cecilie Røe; Erik Bautz-Holter; Nada Andelic; Helene Lundgaard Søberg; Boya Nugraha; Christoph Gutenbrunner; Andrea Boekel; Marit Kirkevold; Grace Engen; Juan Lu
Journal:  Arch Rehabil Res Clin Transl       Date:  2022-04-13

Review 2.  Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis.

Authors:  Emalie Hurkmans; Florus J van der Giesen; Thea Pm Vliet Vlieland; Jan Schoones; E C H M Van den Ende
Journal:  Cochrane Database Syst Rev       Date:  2009-10-07

3.  Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews.

Authors:  Joel J Gagnier; Hal Morgenstern; Doug G Altman; Jesse Berlin; Stephanie Chang; Peter McCulloch; Xin Sun; David Moher
Journal:  BMC Med Res Methodol       Date:  2013-08-30       Impact factor: 4.615

4.  Safety and sedative effect of intranasal dexmedetomidine in mandibular third molar surgery: a systematic review and meta-analysis.

Authors:  Shaopeng Liu; Ye Wang; Yong Zhu; Tingting Yu; Huaqiang Zhao
Journal:  Drug Des Devel Ther       Date:  2019-04-23       Impact factor: 4.162

Review 5.  Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature.

Authors:  Joel J Gagnier; David Moher; Heather Boon; Joseph Beyene; Claire Bombardier
Journal:  BMC Med Res Methodol       Date:  2012-07-30       Impact factor: 4.615

  5 in total

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