Literature DB >> 16894350

Obesity--a risk factor or a RISK factor for myocardial infarction?

G Heusch1.   

Abstract

The detrimental actions of leptin on cardiovascular function are well established. Smith et al. report the novel finding of a reduction of infarct size by exogenous leptin when given at reperfusion. The involvement of the reperfusion injury salvage kinase (RISK) pathway in such reduction of infarct size and its relation to ischemic pre- and postconditioning are discussed and some methodological issues in its assessment are raised. Obesity has possibly opposite effects on the incidence and outcome of myocardial infarction.

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Year:  2006        PMID： 16894350      PMCID： PMC1629413          DOI： 10.1038/sj.bjp.0706833

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  19 in total

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Review 7.  Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection.

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  10 in total

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