Literature DB >> 16894124

Treatment monitoring and response prediction with proton MR spectroscopy in AD.

F Jessen1, F Traeber, K Freymann, W Maier, H H Schild, W Block.   

Abstract

In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

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Year:  2006        PMID： 16894124     DOI： 10.1212/01.wnl.0000228218.68451.31

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  24 in total

Review 1.  Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives.

Authors:  Harald Hampel; Richard Frank; Karl Broich; Stefan J Teipel; Russell G Katz; John Hardy; Karl Herholz; Arun L W Bokde; Frank Jessen; Yvonne C Hoessler; Wendy R Sanhai; Henrik Zetterberg; Janet Woodcock; Kaj Blennow
Journal:  Nat Rev Drug Discov       Date:  2010-07       Impact factor: 84.694

2.  Sodium MR imaging detection of mild Alzheimer disease: preliminary study.

Authors:  E A Mellon; D T Pilkinton; C M Clark; M A Elliott; W R Witschey; A Borthakur; R Reddy
Journal:  AJNR Am J Neuroradiol       Date:  2009-02-12       Impact factor: 3.825

3.  [Novel neuroimaging perspectives in the diagnosis of dementia].

Authors:  F Jessen
Journal:  Nervenarzt       Date:  2008-11       Impact factor: 1.214

4.  [Mild cognitive impairment: diagnostic value of different MR techniques].

Authors:  T Hauser; P A Thomann; B Stieltjes; M Essig
Journal:  Radiologe       Date:  2011-04       Impact factor: 0.635

Review 5.  Various MRS application tools for Alzheimer disease and mild cognitive impairment.

Authors:  F Gao; P B Barker
Journal:  AJNR Am J Neuroradiol       Date:  2014-04-17       Impact factor: 3.825

Review 6.  Bioenergetic medicine.

Authors:  Russell H Swerdlow
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

7.  Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study.

Authors:  Jonathan M Schott; Chris Frost; David G MacManus; Fowzia Ibrahim; Adam D Waldman; Nick C Fox
Journal:  Brain       Date:  2010-08-25       Impact factor: 13.501

8.  Effect of cholinergic signaling on neuronal cell bioenergetics.

Authors:  Jianghua Lu; Lezi E; Nairita Roy; Lewis Hutfles; Eva Selfridge; Eric Funk; Jeffrey M Burns; Russell H Swerdlow
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

Review 9.  Current and future uses of neuroimaging for cognitively impaired patients.

Authors:  Gary W Small; Susan Y Bookheimer; Paul M Thompson; Greg M Cole; S-C Huang; Vladimir Kepe; Jorge R Barrio
Journal:  Lancet Neurol       Date:  2008-02       Impact factor: 44.182

10.  1H-MRS assessment of the therapeutic effect of bilateral intraventricular BDNF infusion into APP/PS1 double transgenic mice.

Authors:  Wei Zhang; Pei-jun Wang; Ming-hua Li; Guo-liang Wang; Ping Li; Xiao-long Gao
Journal:  J Mol Neurosci       Date:  2013-01-15       Impact factor: 3.444
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