Literature DB >> 16894115

Progressive depletion of mtDNA in mitochondrial myopathy.

Steve E Durham1, Denise T Brown, Douglass M Turnbull, Patrick F Chinnery.   

Abstract

The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.

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Year:  2006        PMID： 16894115     DOI： 10.1212/01.wnl.0000227961.55640.2f

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

1.  Depletion of mitochondrial DNA in leucocytes harbouring the 3243A->G mtDNA mutation.

Authors:  Angela Pyle; Robert W Taylor; Steve E Durham; Marcus Deschauer; Andrew M Schaefer; David C Samuels; Patrick F Chinnery
Journal:  J Med Genet       Date:  2006-09-01       Impact factor: 6.318

2.  One complex world of mitochondrial parkinsonism.

Authors:  Patrick F Chinnery
Journal:  Brain       Date:  2013-08       Impact factor: 13.501

3.  Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load.

Authors:  Kieren G Hollingsworth; Grainne S Gorman; Michael I Trenell; Robert McFarland; Robert W Taylor; Douglass M Turnbull; Guy A MacGowan; Andrew M Blamire; Patrick F Chinnery
Journal:  Neuromuscul Disord       Date:  2012-04-17       Impact factor: 4.296

4.  Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Authors:  R Filograna; C Koolmeister; M Upadhyay; A Pajak; P Clemente; R Wibom; M L Simard; A Wredenberg; C Freyer; J B Stewart; N G Larsson
Journal:  Sci Adv       Date:  2019-04-03       Impact factor: 14.136

5.  Critical evaluation of ayurvedic plants for stimulating intrinsic antioxidant response.

Authors:  Sunil Dutt Shukla; Maheep Bhatnagar; Sukant Khurana
Journal:  Front Neurosci       Date:  2012-07-26       Impact factor: 4.677

Review 6.  The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.

Authors:  James B Stewart; Patrick F Chinnery
Journal:  Nat Rev Genet       Date:  2015-09       Impact factor: 53.242
  6 in total

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