| Literature DB >> 16893912 |
Chang-Hsun Hsieh1, Kung-Hao Liang, Yi-Jen Hung, Li-Chin Huang, Dee Pei, Ya-Tang Liao, Shi-Wen Kuo, Monica Shian-Jy Bey, Jui-Lin Chen, Ellson Y Chen.
Abstract
Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study for DN. Association analysis were performed on 231 SNP loci in a cohort of 264 type 2 diabetes patients, followed by the epistasis analysis using the multifactor dimensionality reduction and the genetic algorithm with Boolean algebra. A two-locus epistatic effect of EGFR and RXRG was identified, with a cross-validation consistency of 91.7%.Entities:
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Year: 2006 PMID： 16893912 DOI： 10.1093/hmg/ddl203
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150