Literature DB >> 1689258

Maternal vitamin A restriction alters biochemical development of the brain in rats.

H S Sharma1, U K Misra.   

Abstract

The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 micrograms retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats.

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Year:  1990        PMID： 1689258     DOI： 10.1007/bf02027317

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Studies on metabolism of vitamin A. 1. The biological activity of vitamin A acid in rats.

Authors:  P MALATHI; K S RAO; P S SASTRY; J GANGULY
Journal:  Biochem J       Date:  1963-05       Impact factor: 3.857

2.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Biochemical development of the rat lung: studies on cellular DNA, RNA and protein content in relation to maternal vitamin A status.

Authors:  H S Sharma; U K Misra
Journal:  Z Ernahrungswiss       Date:  1987-06

5.  Vitamin A supply and biochemical development of the rat heart: studies on cellular DNA, RNA and protein.

Authors:  H S Sharma; U K Misra
Journal:  Z Ernahrungswiss       Date:  1988-06

6.  Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status.

Authors:  H S Sharma; U K Misra
Journal:  Biol Neonate       Date:  1986

7.  Vulnerability of developing brain. IX. The effect of nutritional growth retardation on the timing of the brain growth-spurt.

Authors:  J Dobbing; J Sands
Journal:  Biol Neonate       Date:  1971

8.  Quantitative changes in DNA, RNA, and protein during prenatal and postnatal growth in the rat.

Authors:  M Winick; A Noble
Journal:  Dev Biol       Date:  1965-12       Impact factor: 3.582

9.  Developmental pattern of the hepatic DNA, RNA and protein in relation to maternal vitamin A status in rats.

Authors:  H S Sharma; U K Misra
Journal:  Acta Vitaminol Enzymol       Date:  1985

10.  Developmental pattern of DNA and proteins in brain, liver, lung and heart of rats given excess vitamin A postnatally.

Authors:  R R Shukla; H C Joshi; U K Misra
Journal:  Biol Neonate       Date:  1983
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  2 in total

Review 1.  Toxicology of choroid plexus: special reference to metal-induced neurotoxicities.

Authors:  W Zheng
Journal:  Microsc Res Tech       Date:  2001-01-01       Impact factor: 2.769

2.  Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid: effect of lead exposure.

Authors:  W Zheng; Y M Lu; G Y Lu; Q Zhao; O Cheung; W S Blaner
Journal:  Toxicol Sci       Date:  2001-05       Impact factor: 4.849
  2 in total

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