Literature DB >> 16892388

Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor.

Roberto Pellicciari1, Rosa C Rizzo, Gabriele Costantino, Maura Marinozzi, Laura Amori, Paolo Guidetti, Hui-Qiu Wu, Robert Schwarcz.   

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Year:  2006        PMID: 16892388     DOI: 10.1002/cmdc.200500095

Source DB:  PubMed          Journal:  ChemMedChem        ISSN: 1860-7179            Impact factor:   3.466


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  31 in total

1.  Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior.

Authors:  Michelle C Potter; Greg I Elmer; Richard Bergeron; Edson X Albuquerque; Paolo Guidetti; Hui-Qiu Wu; Robert Schwarcz
Journal:  Neuropsychopharmacology       Date:  2010-03-24       Impact factor: 7.853

2.  Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid?

Authors:  Robert Schwarcz; Christopher A Hunter
Journal:  Schizophr Bull       Date:  2007-04-13       Impact factor: 9.306

3.  Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse.

Authors:  Manuela Schmid; Maik J Lehmann; Richard Lucius; Nishith Gupta
Journal:  J Biol Chem       Date:  2012-04-25       Impact factor: 5.157

Review 4.  Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.

Authors:  Qian Han; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  Cell Mol Life Sci       Date:  2009-10-15       Impact factor: 9.261

5.  Targeting kynurenine aminotransferase II in psychiatric diseases: promising effects of an orally active enzyme inhibitor.

Authors:  Hui-Qiu Wu; Masahiro Okuyama; Yasushi Kajii; Ana Pocivavsek; John P Bruno; Robert Schwarcz
Journal:  Schizophr Bull       Date:  2014-03       Impact factor: 9.306

Review 6.  Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis.

Authors:  Eric Plitman; Yusuke Iwata; Fernando Caravaggio; Shinichiro Nakajima; Jun Ku Chung; Philip Gerretsen; Julia Kim; Hiroyoshi Takeuchi; M Mallar Chakravarty; Gary Remington; Ariel Graff-Guerrero
Journal:  Schizophr Bull       Date:  2017-07-01       Impact factor: 9.306

7.  Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement.

Authors:  Franca Rossi; Casazza Valentina; Silvia Garavaglia; Korrapati V Sathyasaikumar; Robert Schwarcz; Shin-Ichi Kojima; Keisuke Okuwaki; Shin-Ichiro Ono; Yasushi Kajii; Menico Rizzi
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

Review 8.  Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.

Authors:  Sophie Erhardt; Sara K Olsson; Göran Engberg
Journal:  CNS Drugs       Date:  2009       Impact factor: 5.749

9.  Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development.

Authors:  Manuela Schmid; Emanuel Heitlinger; Simone Spork; Hans-Joachim Mollenkopf; Richard Lucius; Nishith Gupta
Journal:  Mucosal Immunol       Date:  2013-12-25       Impact factor: 7.313

10.  The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.

Authors:  Hui-Qiu Wu; Edna F R Pereira; John P Bruno; Roberto Pellicciari; Edson X Albuquerque; Robert Schwarcz
Journal:  J Mol Neurosci       Date:  2009-08-19       Impact factor: 3.444

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