Literature DB >> 16892160

The Genetic Basis of Type 2 Diabetes.

Swapan Kumar Das1, Steven C Elbein.   

Abstract

Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like molecules from adipocytes, hepatic glucose production, and likely the central nervous system. Consistent with the complex web of physiologic defects, the emerging picture of the genetics will involve a large number of risk susceptibility genes, each individually with relatively small effect (odds ratios below 1.2 in most cases). The challenge for the future will include cataloging and confirming the genetic risk factors, and understanding how these risk factors interact with each other and with the known environmental and lifestyle risk factors that increase the propensity to type 2 diabetes.

Entities:  

Year:  2006        PMID： 16892160      PMCID： PMC1526773          DOI： 10.1901/jaba.2006.2-100

Source DB:  PubMed          Journal:  Cellscience        ISSN： 1742-8130


  186 in total

1.  Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Authors:  C Y Zhang; G Baffy; P Perret; S Krauss; O Peroni; D Grujic; T Hagen; A J Vidal-Puig; O Boss; Y B Kim; X X Zheng; M B Wheeler; G I Shulman; C B Chan; B B Lowell
Journal:  Cell       Date:  2001-06-15       Impact factor: 41.582

2.  The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

Authors:  Kentaro Ozawa; Mayuki Miyazaki; Munehide Matsuhisa; Katsura Takano; Yoshihisa Nakatani; Masahiro Hatazaki; Takashi Tamatani; Kazuya Yamagata; Jun-Ichiro Miyagawa; Yasuko Kitao; Osamu Hori; Yoshimitsu Yamasaki; Satoshi Ogawa
Journal:  Diabetes       Date:  2005-03       Impact factor: 9.461

3.  Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians.

Authors:  K S Vimaleswaran; V Radha; S Ghosh; P P Majumder; R Deepa; H N S Babu; M R S Rao; V Mohan
Journal:  Diabet Med       Date:  2005-11       Impact factor: 4.359

4.  A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.

Authors:  L J Baier; P A Permana; X Yang; R E Pratley; R L Hanson; G Q Shen; D Mott; W C Knowler; N J Cox; Y Horikawa; N Oda; G I Bell; C Bogardus
Journal:  J Clin Invest       Date:  2000-10       Impact factor: 14.808

5.  A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study.

Authors:  James B Meigs; Carolien I M Panhuysen; Richard H Myers; Peter W F Wilson; L Adrienne Cupples
Journal:  Diabetes       Date:  2002-03       Impact factor: 9.461

6.  Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.

Authors:  Steven C Elbein; Winston Chu; Qianfang Ren; Chris Hemphill; John Schay; Nancy J Cox; Craig L Hanis; Sandra J Hasstedt
Journal:  J Clin Endocrinol Metab       Date:  2002-02       Impact factor: 5.958

7.  Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.

Authors:  N Matsuoka; A Patki; H K Tiwari; D B Allison; S B Johnson; P K Gregersen; R L Leibel; W K Chung
Journal:  Int J Obes (Lond)       Date:  2006-02       Impact factor: 5.095

8.  A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27.

Authors:  S Francke; M Manraj; C Lacquemant; C Lecoeur; F Leprêtre; P Passa; A Hebe; L Corset; S L Yan; S Lahmidi; S Jankee; T K Gunness; U S Ramjuttun; V Balgobin; C Dina; P Froguel
Journal:  Hum Mol Genet       Date:  2001-11-15       Impact factor: 6.150

9.  The transcriptional landscape of the mammalian genome.

Authors:  P Carninci; T Kasukawa; S Katayama; J Gough; M C Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; V B Bajic; S E Brenner; S Batalov; A R R Forrest; M Zavolan; M J Davis; L G Wilming; V Aidinis; J E Allen; A Ambesi-Impiombato; R Apweiler; R N Aturaliya; T L Bailey; M Bansal; L Baxter; K W Beisel; T Bersano; H Bono; A M Chalk; K P Chiu; V Choudhary; A Christoffels; D R Clutterbuck; M L Crowe; E Dalla; B P Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; C F Fletcher; T Fukushima; M Furuno; S Futaki; M Gariboldi; P Georgii-Hemming; T R Gingeras; T Gojobori; R E Green; S Gustincich; M Harbers; Y Hayashi; T K Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; K Ikeo; A Iwama; T Ishikawa; M Jakt; A Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; G Kollias; S P T Krishnan; A Kruger; S K Kummerfeld; I V Kurochkin; L F Lareau; D Lazarevic; L Lipovich; J Liu; S Liuni; S McWilliam; M Madan Babu; M Madera; L Marchionni; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Y Okazaki; V Orlando; K C Pang; W J Pavan; G Pavesi; G Pesole; N Petrovsky; S Piazza; J Reed; J F Reid; B Z Ring; M Ringwald; B Rost; Y Ruan; S L Salzberg; A Sandelin; C Schneider; C Schönbach; K Sekiguchi; C A M Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; E Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; S L Tan; S Tang; M S Taylor; J Tegner; S A Teichmann; H R Ueda; E van Nimwegen; R Verardo; C L Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; W Hide; C Bult; S M Grimmond; R D Teasdale; E T Liu; V Brusic; J Quackenbush; C Wahlestedt; J S Mattick; D A Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; M Itoh; T Kato; H Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; K Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

10.  The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.

Authors:  S Ghosh; R M Watanabe; T T Valle; E R Hauser; V L Magnuson; C D Langefeld; D S Ally; K L Mohlke; K Silander; K Kohtamäki; P Chines; J Balow; G Birznieks; J Chang; W Eldridge; M R Erdos; Z E Karanjawala; J I Knapp; K Kudelko; C Martin; A Morales-Mena; A Musick; T Musick; C Pfahl; R Porter; J B Rayman
Journal:  Am J Hum Genet       Date:  2000-10-13       Impact factor: 11.043
View more
  48 in total

1.  The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications.

Authors:  Chun Zeng; Xiaoyun Shi; Baojun Zhang; He Liu; Lianjun Zhang; Wenjun Ding; Yong Zhao
Journal:  J Mol Med (Berl)       Date:  2011-10-01       Impact factor: 4.599

2.  Haptoglobin 2-2 genotype is associated with increased risk of type 2 diabetes mellitus in northern Chinese.

Authors:  Xiaohong Shi; Liang Sun; Li Wang; Feng Jin; Junfeng Sun; Xiaoquan Zhu; Lei Tang; Yanchun Qu; Ze Yang
Journal:  Genet Test Mol Biomarkers       Date:  2012-02-02

3.  Sideways Glance: Genome wide association studies for type 2 diabetes mellitus.

Authors:  Yula Sambuy
Journal:  Genes Nutr       Date:  2007-12       Impact factor: 5.523

4.  Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.

Authors:  Rebekah L Craig; Winston S Chu; Steven C Elbein
Journal:  Mol Genet Metab       Date:  2006-12-14       Impact factor: 4.797

Review 5.  Genetics factors contributing to type 2 diabetes across ethnicities.

Authors:  Steven C Elbein
Journal:  J Diabetes Sci Technol       Date:  2009-07-01

6.  Multi-locus models of genetic risk of disease.

Authors:  Naomi R Wray; Michael E Goddard
Journal:  Genome Med       Date:  2010-02-02       Impact factor: 11.117

Review 7.  Diabetes mellitus and burns. Part I-basic science and implications for management.

Authors:  Ioannis Goutos; Rebecca Spenser Nicholas; Atisha A Pandya; Sudip J Ghosh
Journal:  Int J Burns Trauma       Date:  2015-03-20

Review 8.  Current views on type 2 diabetes.

Authors:  Yi Lin; Zhongjie Sun
Journal:  J Endocrinol       Date:  2009-09-21       Impact factor: 4.286

9.  The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies.

Authors:  Karla J Lindquist; Eric Jorgenson; Thomas J Hoffmann; John S Witte
Journal:  Genet Epidemiol       Date:  2013-03-25       Impact factor: 2.135

10.  The genetic interpretation of area under the ROC curve in genomic profiling.

Authors:  Naomi R Wray; Jian Yang; Michael E Goddard; Peter M Visscher
Journal:  PLoS Genet       Date:  2010-02-26       Impact factor: 5.917
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.