OBJECTIVE: To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obese children and adolescents. DESIGN: We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure. MEASUREMENTS: Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR). RESULTS: CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP. CONCLUSIONS: These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life.
OBJECTIVE: To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obesechildren and adolescents. DESIGN: We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure. MEASUREMENTS: Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR). RESULTS:CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP. CONCLUSIONS: These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life.
Authors: Yannis Manios; K Karatzi; A D Protogerou; G Moschonis; C Tsirimiagou; O Androutsos; C Lionis; G P Chrousos Journal: Eur J Nutr Date: 2017-03-27 Impact factor: 5.614
Authors: Caroline Brand; Ana Paula Sehn; Camila Felin Fochesatto; João Francisco de Castro Silveira; Jorge Mota; David Martinez Gomez; Anelise Reis Gaya; Cézane Priscila Reuter; Jane Dagmar Pollo Renner Journal: BMC Cardiovasc Disord Date: 2022-06-15 Impact factor: 2.174
Authors: Laura Mihaela Trandafir; Elena Cojocaru; Mihaela Moscalu; Maria Magdalena Leon Constantin; Ingrith Miron; Alexandra Mastaleru; Oana Teslariu; Madalina Elena Datcu; Silvia Fotea; Otilia Frăsinariu Journal: Diagnostics (Basel) Date: 2021-04-20