Literature DB >> 16891615

Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat.

Joachim D K Uys1, Lelanie Marais, Jacqueline Faure, Desiree Prevoo, Pieter Swart, Abdul H Mohammed, Dan J Stein, Willie M U Daniels.   

Abstract

Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.

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Year:  2006        PMID： 16891615     DOI： 10.1196/annals.1364.060

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  17 in total

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3.  Cognitive impact of social stress and coping strategy throughout development.

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4.  The effects of repetitive stress on tat protein-induced pro-inflammatory cytokine release and steroid receptor expression in the hippocampus of rats.

Authors:  Khayelihle B Makhathini; Oualid Abboussi; Musa V Mabandla; William M U Daniels
Journal:  Metab Brain Dis       Date:  2018-07-10       Impact factor: 3.584

5.  The default mode network and self-referential processes in depression.

Authors:  Yvette I Sheline; Deanna M Barch; Joseph L Price; Melissa M Rundle; S Neil Vaishnavi; Abraham Z Snyder; Mark A Mintun; Suzhi Wang; Rebecca S Coalson; Marcus E Raichle
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-26       Impact factor: 11.205

6.  Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.

Authors:  Lara G Chepenik; Carolyn Fredericks; Xenophon Papademetris; Linda Spencer; Cheryl Lacadie; Fei Wang; Brian Pittman; James S Duncan; Lawrence H Staib; Ronald S Duman; Joel Gelernter; Hilary P Blumberg
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7.  Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors.

Authors:  Jacqueline Faure; Joachim D K Uys; Lelanie Marais; Dan J Stein; Willie M U Daniels
Journal:  Metab Brain Dis       Date:  2007-04-29       Impact factor: 3.584

8.  Maternal separation fails to render animals more susceptible to methamphetamine-induced conditioned place preference.

Authors:  Jacqueline Faure; Dan J Stein; William Daniels
Journal:  Metab Brain Dis       Date:  2009-10-10       Impact factor: 3.584

9.  Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 1(7) glucocorticoid receptor promoter region.

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Journal:  Metab Brain Dis       Date:  2009-10-09       Impact factor: 3.584

10.  Large scale hippocampal cellular distress may explain the behavioral consequences of repetitive traumatic experiences--a proteomic approach.

Authors:  Joachim D K Uys; Suzél M Hattingh; Dan J Stein; Willie M U Daniels
Journal:  Neurochem Res       Date:  2008-02-29       Impact factor: 3.996
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