Literature DB >> 16891541

Azole resistance of Candida glabrata in a case of recurrent fungemia.

Brunella Posteraro1, Mario Tumbarello, Marilena La Sorda, Teresa Spanu, Enrico Maria Trecarichi, Flavia De Bernardis, Giancarlo Scoppettuolo, Maurizio Sanguinetti, Giovanni Fadda.   

Abstract

We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.

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Year:  2006        PMID： 16891541      PMCID： PMC1594598          DOI： 10.1128/JCM.00526-06

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  13 in total

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3.  Maternal sepsis and intrauterine fetal death resulting from Candida tropicalis chorioamnionitis in a woman with a retained intrauterine contraceptive device.

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4.  Comparison of results of voriconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program.

Authors:  M A Pfaller; L Boyken; S A Messer; S Tendolkar; R J Hollis; D J Diekema
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

5.  The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents.

Authors:  D Sanglard; F Ischer; D Calabrese; P A Majcherczyk; J Bille
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

6.  Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance.

Authors:  Maurizio Sanguinetti; Brunella Posteraro; Barbara Fiori; Stefania Ranno; Riccardo Torelli; Giovanni Fadda
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

7.  Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiation.

Authors:  Spencer W Redding; William R Kirkpatrick; Stephen Saville; Brent J Coco; William White; Annette Fothergill; Michael Rinaldi; Tony Eng; Thomas F Patterson; Jose Lopez-Ribot
Journal:  J Clin Microbiol       Date:  2003-02       Impact factor: 5.948

8.  Multilocus sequence typing of Candida glabrata reveals geographically enriched clades.

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10.  Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.

Authors:  H Miyazaki; Y Miyazaki; A Geber; T Parkinson; C Hitchcock; D J Falconer; D J Ward; K Marsden; J E Bennett
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  5 in total

1.  Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole.

Authors:  A Espinel-Ingroff; M A Pfaller; B Bustamante; E Canton; A Fothergill; J Fuller; G M Gonzalez; C Lass-Flörl; S R Lockhart; E Martin-Mazuelos; J F Meis; M S C Melhem; L Ostrosky-Zeichner; T Pelaez; M W Szeszs; G St-Germain; L X Bonfietti; J Guarro; J Turnidge
Journal:  Antimicrob Agents Chemother       Date:  2014-01-13       Impact factor: 5.191

2.  Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice.

Authors:  Sélène Ferrari; Maurizio Sanguinetti; Flavia De Bernardis; Riccardo Torelli; Brunella Posteraro; Patrick Vandeputte; Dominique Sanglard
Journal:  Antimicrob Agents Chemother       Date:  2011-02-14       Impact factor: 5.191

3.  Fungal Profile of Vulvovaginal Candidiasis in a Tertiary Care Hospital.

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Journal:  J Clin Diagn Res       Date:  2017-03-01

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5.  Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole.

Authors:  Sofía Siscar-Lewin; Toni Gabaldón; Alexander M Aldejohann; Oliver Kurzai; Bernhard Hube; Sascha Brunke
Journal:  mBio       Date:  2021-06-01       Impact factor: 7.867
  5 in total

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