Literature DB >> 16890916

Polyamine synthesis and salvage pathways in the malaria parasite Plasmodium falciparum.

T N C Ramya1, Namita Surolia, Avadhesha Surolia.   

Abstract

We demonstrate, for the first time, a functional polyamine biosynthetic pathway in the malaria parasite Plasmodium falciparum that culminates in the synthesis of spermine. Additionally, we also report putrescine and spermidine salvage in the malaria parasite. Putrescine and spermidine transport in P. falciparum infected red blood cells is a highly specific, carrier mediated and active process, mediated by new transporters that differ from the transporters of uninfected red blood cells in their kinetic parameters, Vmax and km, as well as in their activation energy.

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Year:  2006        PMID： 16890916     DOI： 10.1016/j.bbrc.2006.07.127

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin.

Authors:  Shivendra G Tewari; Krithika Rajaram; Russell P Swift; Jaques Reifman; Sean T Prigge; Anders Wallqvist
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

2.  Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.

Authors:  Germán Plata; Tzu-Lin Hsiao; Kellen L Olszewski; Manuel Llinás; Dennis Vitkup
Journal:  Mol Syst Biol       Date:  2010-09-07       Impact factor: 11.429

Review 3.  Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.

Authors:  Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I Louw; Lo Persson; Olle Heby
Journal:  Biochem J       Date:  2011-09-01       Impact factor: 3.857

4.  Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression.

Authors:  E Yaneth Osorio; Weiguo Zhao; Claudia Espitia; Omar Saldarriaga; Leo Hawel; Craig V Byus; Bruno L Travi; Peter C Melby
Journal:  PLoS Pathog       Date:  2012-01-19       Impact factor: 6.823

5.  Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites.

Authors:  Audrey C Brown; Christopher C Moore; Jennifer L Guler
Journal:  Sci Rep       Date:  2020-03-12       Impact factor: 4.379

6.  Plasmodium falciparum S-Adenosylmethionine Synthetase Is Essential for Parasite Survival through a Complex Interaction Network with Cytoplasmic and Nuclear Proteins.

Authors:  Jean Pierre Musabyimana; Ute Distler; Juliane Sassmannshausen; Christina Berks; Janice Manti; Sandra Bennink; Lea Blaschke; Paul-Christian Burda; Ansgar Flammersfeld; Stefan Tenzer; Che Julius Ngwa; Gabriele Pradel
Journal:  Microorganisms       Date:  2022-07-14

7.  Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells.

Authors:  Rachna Hora; Daniel J Bridges; Alister Craig; Amit Sharma
Journal:  J Biol Chem       Date:  2009-01-08       Impact factor: 5.157

8.  Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design.

Authors:  Janina Sprenger; Bo Svensson; Jenny Hålander; Jannette Carey; Lo Persson; Salam Al-Karadaghi
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-02-26

9.  Plasmodium AdoMetDC/ODC bifunctional enzyme is essential for male sexual stage development and mosquito transmission.

Authors:  Robert J Hart; Atif Ghaffar; Shaymaa Abdalal; Benjamin Perrin; Ahmed S I Aly
Journal:  Biol Open       Date:  2016-08-15       Impact factor: 2.422

10.  Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.

Authors:  Janina Sprenger; Jannette Carey; Bo Svensson; Verena Wengel; Lo Persson
Journal:  PLoS One       Date:  2016-09-23       Impact factor: 3.240
  10 in total

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