Literature DB >> 16890433

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

Sandra Gemma1, Gagan Kukreja, Caterina Fattorusso, Marco Persico, Maria P Romano, Maria Altarelli, Luisa Savini, Giuseppe Campiani, Ernesto Fattorusso, Nicoletta Basilico, Donatella Taramelli, Vanessa Yardley, Stefania Butini.   

Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.

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Year:  2006        PMID： 16890433     DOI： 10.1016/j.bmcl.2006.07.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.

Authors:  Marco Paolino; Mariagrazia Rullo; Samuele Maramai; Modesto de Candia; Leonardo Pisani; Marco Catto; Claudia Mugnaini; Antonella Brizzi; Andrea Cappelli; Massimo Olivucci; Federico Corelli; Cosimo D Altomare
Journal:  RSC Med Chem       Date:  2022-06-01

Review 3.  Biological activities of hydrazone derivatives.

Authors:  Sevim Rollas; S Güniz Küçükgüzel
Journal:  Molecules       Date:  2007-08-17       Impact factor: 4.411

4.  Structural modifications of quinoline-based antimalarial agents: Recent developments.

Authors:  Sandhya Bawa; Suresh Kumar; Sushma Drabu; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2010-04

5.  N'-[(5-Methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(thio-phen-2-yl)methyl-idene]benzohydrazide.

Authors:  Hualing Zhu; Jinhua Zhu; Luxia Bu; Jun Shi; Juan Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-13

6.  Benzoquinoline amines - Key intermediates for the synthesis of angular and linear dinaphthonaphthyridines.

Authors:  Kolandaivel Prabha; K J Rajendra Prasad
Journal:  J Adv Res       Date:  2014-03-05       Impact factor: 10.479

7.  Synthesis, biological evaluation and 2D-QSAR study of halophenyl bis-hydrazones as antimicrobial and antitubercular agents.

Authors:  Hatem A Abdel-Aziz; Wagdy M Eldehna; Mohamed Fares; Sara T A Al-Rashood; Khalid A Al-Rashood; Marwa M Abdel-Aziz; Dalia H Soliman
Journal:  Int J Mol Sci       Date:  2015-04-20       Impact factor: 5.923

8.  Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.

Authors:  Zengyang Xie; Yuying Song; Lujia Xu; Yukun Guo; Min Zhang; Limei Li; Kai Chen; Xue Liu
Journal:  ChemistryOpen       Date:  2018-11-21       Impact factor: 2.911

9.  1-{(E)-[5-(2-Nitro-phen-yl)furan-2-yl]methyl-idene}-2,2-diphenyl-hydrazine.

Authors:  Marcos Flores-Alamo; Blanca M Cabrera-Vivas; Ruth Meléndrez-Luevano; Julio M Hernández P; Lena Ruiz-Azuara
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-15

10.  Syntheses, spectral characterization, and antimicrobial studies on the coordination compounds of metal ions with schiff base containing both aliphatic and aromatic hydrazide moieties.

Authors:  Dinesh Kumar; Silky Chadda; Jyoti Sharma; Parveen Surain
Journal:  Bioinorg Chem Appl       Date:  2013-10-03       Impact factor: 7.778
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