Literature DB >> 1689004

The effects of a range of anti-cancer drugs in the white-ivory somatic mutation test in Drosophila.

J Clements1, D Howe, A Lowry, M Phillips.   

Abstract

The white-ivory test is based upon the reversion of the X-linked, recessive eye-colour mutation white-ivory to wild-type. Somatic reversion of white-ivory results in clones of red facets in the white-ivory eyes of eclosing adult flies. 4 anti-cancer drugs, bleomycin, adriamycin, mitoxantrone and cyclophosphamide were found to significantly increase the white-ivory reversion frequency whereas cytosine arabinoside, methotrexate and vincristine did not give positive results.

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Year:  1990        PMID: 1689004     DOI: 10.1016/0027-5107(90)90073-d

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  3 in total

1.  Genotoxic evaluation of ten carcinogens in the Drosophila melanogaster wing spot test.

Authors:  M Batiste-Alentorn; N Xamena; A Creus; R Marcos
Journal:  Experientia       Date:  1995-01-15

2.  Mammalian genes expressed in Drosophila: a transgenic model for the study of mechanisms of chemical mutagenesis and metabolism.

Authors:  T Jowett; M F Wajidi; E Oxtoby; C R Wolf
Journal:  EMBO J       Date:  1991-05       Impact factor: 11.598

3.  Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells.

Authors:  Anthony Edwards; Mara Gladstone; Petros Yoon; David Raben; Barbara Frederick; Tin Tin Su
Journal:  Dis Model Mech       Date:  2011-04-18       Impact factor: 5.758

  3 in total

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