AIM: The aim of this report was to assess the strength and influence of periodontitis as a possible risk factor for pre-term birth (PTB) in a cohort of 81 primiparous Croatian mothers aged 18-39 years. METHODS: PTB cases (n = 17; mean age 25 +/- 2.9 years; age range 20-33 years) were defined as spontaneous delivery after less than 37 completed weeks of gestation that were followed by spontaneous labour or spontaneous rupture of membranes. Controls (full-time births) were normal births at or after 37 weeks of gestation (n = 64; mean age 25 +/- 2.9 years; age range 19-39 years). Information on known risk factors and obstetric factors included the current pregnancy history, maternal age at delivery, pre-natal care, nutritional status, tobacco use, alcohol use, genitourinary infections, vaginosis, gestational age, and birth weight. Full-mouth periodontal examination was performed on all mothers within 2 days of delivery. RESULTS: PTB cases had significantly worse periodontal status than controls (p = 0.008). Multivariate logistic regression model, after controlling for other risk factors, demonstrated that periodontal disease is a significant independent risk factor for PTB, with an adjusted odds ratio of 8.13 for the PTB group (95% confidence interval 2.73-45.9). CONCLUSION: Periodontal disease represents a strong, independent, and clinically significant risk factor for PTB in the studied cohort. There are strong indicators that periodontal therapy should form a part of preventive prenatal care in Croatia.
AIM: The aim of this report was to assess the strength and influence of periodontitis as a possible risk factor for pre-term birth (PTB) in a cohort of 81 primiparous Croatian mothers aged 18-39 years. METHODS: PTB cases (n = 17; mean age 25 +/- 2.9 years; age range 20-33 years) were defined as spontaneous delivery after less than 37 completed weeks of gestation that were followed by spontaneous labour or spontaneous rupture of membranes. Controls (full-time births) were normal births at or after 37 weeks of gestation (n = 64; mean age 25 +/- 2.9 years; age range 19-39 years). Information on known risk factors and obstetric factors included the current pregnancy history, maternal age at delivery, pre-natal care, nutritional status, tobacco use, alcohol use, genitourinary infections, vaginosis, gestational age, and birth weight. Full-mouth periodontal examination was performed on all mothers within 2 days of delivery. RESULTS: PTB cases had significantly worse periodontal status than controls (p = 0.008). Multivariate logistic regression model, after controlling for other risk factors, demonstrated that periodontal disease is a significant independent risk factor for PTB, with an adjusted odds ratio of 8.13 for the PTB group (95% confidence interval 2.73-45.9). CONCLUSION:Periodontal disease represents a strong, independent, and clinically significant risk factor for PTB in the studied cohort. There are strong indicators that periodontal therapy should form a part of preventive prenatal care in Croatia.
Authors: Rohini Govindasamy; Manikandan Dhanasekaran; Sheeja S Varghese; V R Balaji; B Karthikeyan; Ananthi Christopher Journal: J Pharm Bioallied Sci Date: 2017-11
Authors: Mohammad Sajjad Ghaemi; Daniel B DiGiulio; Kévin Contrepois; Benjamin Callahan; Thuy T M Ngo; Brittany Lee-McMullen; Benoit Lehallier; Anna Robaczewska; David Mcilwain; Yael Rosenberg-Hasson; Ronald J Wong; Cecele Quaintance; Anthony Culos; Natalie Stanley; Athena Tanada; Amy Tsai; Dyani Gaudilliere; Edward Ganio; Xiaoyuan Han; Kazuo Ando; Leslie McNeil; Martha Tingle; Paul Wise; Ivana Maric; Marina Sirota; Tony Wyss-Coray; Virginia D Winn; Maurice L Druzin; Ronald Gibbs; Gary L Darmstadt; David B Lewis; Vahid Partovi Nia; Bruno Agard; Robert Tibshirani; Garry Nolan; Michael P Snyder; David A Relman; Stephen R Quake; Gary M Shaw; David K Stevenson; Martin S Angst; Brice Gaudilliere; Nima Aghaeepour Journal: Bioinformatics Date: 2019-01-01 Impact factor: 6.937
Authors: Kathleen M Antony; Judy Levison; Melissa A Suter; Susan Raine; Grace Chiudzu; Henry Phiri; Joseph Sclafani; Michael Belfort; Peter Kazembe; Kjersti M Aagaard Journal: Int J Womens Health Date: 2019-01-30