Literature DB >> 16888791

Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

Hua Cao1, George Stamatoyannopoulos.   

Abstract

We investigated the induction of the human fetal globin gene using five potent histone deacetylase (HDAC) inhibitors: FK-228, HC-Toxin, Trichostatin, MS-275, and Apicidin, using in vitro assays and cultures of primary human erythroblasts. The results showed that FK228 is the most potent inducer of fetal hemoglobin and exhibits its effects in picomolar concentrations. FK228 should be considered as a potential therapeutic for induction of fetal hemoglobin in patients with beta chain hemoglobinopathies.

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Year:  2006        PMID： 16888791     DOI： 10.1002/ajh.20676

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  8 in total

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Authors:  Susan E Bates; Zhirong Zhan; Kenneth Steadman; Tomasz Obrzut; Victoria Luchenko; Robin Frye; Robert W Robey; Maria Turner; Erin R Gardner; William D Figg; Seth M Steinberg; Alex Ling; Tito Fojo; Kin Wah To; Richard L Piekarz
Journal:  Br J Haematol       Date:  2009-10-28       Impact factor: 6.998

Review 2.  Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.

Authors:  Robert M Williams
Journal:  J Org Chem       Date:  2011-04-12       Impact factor: 4.354

Review 3.  Fetal haemoglobin induction in sickle cell disease.

Authors:  Alireza Paikari; Vivien A Sheehan
Journal:  Br J Haematol       Date:  2017-11-16       Impact factor: 6.998

4.  Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.

Authors:  Erica B Esrick; Marie McConkey; Katherine Lin; Alyse Frisbee; Benjamin L Ebert
Journal:  Am J Hematol       Date:  2015-05-28       Impact factor: 10.047

Review 5.  Hemoglobin genetics: recent contributions of GWAS and gene editing.

Authors:  Elenoe C Smith; Stuart H Orkin
Journal:  Hum Mol Genet       Date:  2016-06-23       Impact factor: 6.150

6.  Phase I trial of a new schedule of romidepsin in patients with advanced cancers.

Authors:  Laleh Amiri-Kordestani; Victoria Luchenko; Cody J Peer; Kambiz Ghafourian; James Reynolds; Deb Draper; Robin Frye; Sue Woo; David Venzon; John Wright; Monica Skarulis; William D Figg; Tito Fojo; Susan E Bates; Richard L Piekarz
Journal:  Clin Cancer Res       Date:  2013-06-11       Impact factor: 12.531

7.  FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.

Authors:  Levi Makala; Salvatore Di Maro; Tzu-Fang Lou; Sharanya Sivanand; Jung-Mo Ahn; Betty S Pace
Journal:  Anemia       Date:  2012-05-14

8.  Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2.

Authors:  Jeffrey R Shearstone; Olga Golonzhka; Apurva Chonkar; David Tamang; John H van Duzer; Simon S Jones; Matthew B Jarpe
Journal:  PLoS One       Date:  2016-04-13       Impact factor: 3.240
  8 in total

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