Literature DB >> 16888220

Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina.

Tamotsu Seki1, Masayoshi Nakatani, Chisato Taki, Yuko Shinohara, Motoki Ozawa, Shigeru Nishimura, Hiroyuki Ito, Seiji Shioda.   

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.

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Year:  2006        PMID： 16888220     DOI： 10.1196/annals.1317.074

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  19 in total

1.  Pituitary adenylate cyclase-activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells.

Authors:  Laszlo Mester; Krisztina Kovacs; Boglarka Racz; Izabella Solti; Tamas Atlasz; Krisztina Szabadfi; Andrea Tamas; Dora Reglodi
Journal:  J Mol Neurosci       Date:  2010-07-20       Impact factor: 3.444

2.  Effects of PACAP in UV-A radiation-induced retinal degeneration models in rats.

Authors:  Tamas Atlasz; Krisztina Szabadfi; Peter Kiss; Zsuzsanna Marton; Monika Griecs; Levente Hamza; Valeria Gaal; Zsolt Biro; Andrea Tamas; Gabor Hild; Miklos Nyitrai; Gabor Toth; Dora Reglodi; Robert Gabriel
Journal:  J Mol Neurosci       Date:  2010-06-03       Impact factor: 3.444

3.  Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure.

Authors:  Tamotsu Seki; Hiroyuki Itoh; Tomoya Nakamachi; Kimi Endo; Yoshihiro Wada; Keisuke Nakamura; Seiji Shioda
Journal:  J Mol Neurosci       Date:  2010-06-29       Impact factor: 3.444

4.  Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo.

Authors:  K Szabadfi; T Atlasz; P Kiss; B Danyadi; A Tamas; Zs Helyes; H Hashimoto; N Shintani; A Baba; G Toth; R Gabriel; D Reglodi
Journal:  Neurotox Res       Date:  2011-06-30       Impact factor: 3.911

5.  PACAP improves functional outcome in excitotoxic retinal lesion: an electroretinographic study.

Authors:  Balazs Varga; Krisztina Szabadfi; Peter Kiss; Eszter Fabian; Andrea Tamas; Monika Griecs; Robert Gabriel; Dora Reglodi; Adam Kemeny-Beke; Zsuzsanna Pamer; Zsolt Biro; Arpad Tosaki; Tamas Atlasz; Bela Juhasz
Journal:  J Mol Neurosci       Date:  2010-06-22       Impact factor: 3.444

6.  Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.

Authors:  Kimi Endo; Tomoya Nakamachi; Tamotsu Seki; Nobuyuki Kagami; Yoshihiro Wada; Keisuke Nakamura; Koji Kishimoto; Motohide Hori; Daisuke Tsuchikawa; Norihito Shinntani; Hitoshi Hashimoto; Akemichi Baba; Ryohei Koide; Seiji Shioda
Journal:  J Mol Neurosci       Date:  2010-08-12       Impact factor: 3.444

7.  Protective effects of vasoactive intestinal peptide (VIP) in ischemic retinal degeneration.

Authors:  K Szabadfi; B Danyadi; P Kiss; A Tamas; E Fabian; R Gabriel; D Reglodi
Journal:  J Mol Neurosci       Date:  2012-04-29       Impact factor: 3.444

8.  Vasoactive neuropeptides in clinical ophthalmology: An association with autoimmune retinopathy?

Authors:  Donald R Staines; Ekua W Brenu; Sonya Marshall-Gradisnik
Journal:  Clin Ophthalmol       Date:  2009-06-02

Review 9.  Novel neuroprotective strategies in ischemic retinal lesions.

Authors:  Krisztina Szabadfi; Laszlo Mester; Dora Reglodi; Peter Kiss; Norbert Babai; Boglarka Racz; Krisztina Kovacs; Aliz Szabo; Andrea Tamas; Robert Gabriel; Tamas Atlasz
Journal:  Int J Mol Sci       Date:  2010-02-03       Impact factor: 6.208

10.  Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the PKA-Bad-14-3-3 signaling pathway in glutamate-induced retinal injury in neonatal rats.

Authors:  Boglárka Rácz; Ferenc Gallyas; Péter Kiss; Andrea Tamás; Andrea Lubics; István Lengvári; Erzsébet Röth; Gábor Tóth; Orsolya Hegyi; Zsófia Verzál; Csaba Fabricsek; Dóra Reglódi
Journal:  Neurotox Res       Date:  2007-09       Impact factor: 3.911
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