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Literature DB >> 16888218

Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease.

D Reglódi¹, A Tamás, I Lengvári, G Toth, L Szalontay, A Lubics.

Abstract

We have previously shown that PACAP ameliorates the neurological symptoms and reduces the dopaminergic cell loss in young male rats, in a 6-hydroxydopamine (6-OHDA)-induced lesion of the substantia nigra, a model of Parkinson's disease. In the present study, we compared the effects of PACAP in young, aging, and castrated males. Our results show that PACAP significantly reduced the dopaminergic cell loss in young and aging males. In castrated males, 6-OHDA did not induce such a severe cell loss, and it was not altered by PACAP. However, PACAP effectively ameliorated behavioral symptoms in all groups, with a degree of recovery depending on age and endocrine status.

Entities: Chemical Disease Gene Species

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Year: 2006 PMID： 16888218 DOI： 10.1196/annals.1317.072

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

12 in total

1. PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.

Authors: Dwayne Brown; Andrea Tamas; Dora Reglödi; Yousef Tizabi
Journal: J Mol Neurosci Date: 2013-04-28 Impact factor: 3.444

2. Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys.

Authors: M Feher; B Gaszner; A Tamas; A L Gil-Martinez; E Fernandez-Villalba; M T Herrero; D Reglodi
Journal: Neurotox Res Date: 2017-12-11 Impact factor: 3.911

3. Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.

Authors: Paul S Baxter; Marc-Andre Martel; Aoife McMahon; Peter C Kind; Giles E Hardingham
Journal: J Neurochem Date: 2011-06-17 Impact factor: 5.372

Review 4. PACAP deficiency as a model of aging.

Authors: D Reglodi; T Atlasz; E Szabo; A Jungling; A Tamas; T Juhasz; B D Fulop; A Bardosi
Journal: Geroscience Date: 2018-10-22 Impact factor: 7.713

5. PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Authors: Cornelia Ringer; Luisa-Sybille Büning; Martin K H Schäfer; Lee E Eiden; Eberhard Weihe; Burkhard Schütz
Journal: Neurobiol Dis Date: 2013-03-04 Impact factor: 5.996

6. Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

Authors: Shiva Kumar; Augen Pioszak; Chenghai Zhang; Kunchithapadam Swaminathan; H Eric Xu
Journal: PLoS One Date: 2011-05-19 Impact factor: 3.240

Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease.

1. PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.

2. Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys.

3. Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.

Review 4. PACAP deficiency as a model of aging.

5. PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

6. Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

7. Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats.

8. Enriched environment elevates expression of growth associated protein-43 in the substantia nigra of SAMP8 mice.

9. PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis.

10. Alzheimer's Disease Mouse as a Model of Testis Degeneration.