Literature DB >> 16887862

The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials.

Maarten Boers1, Marco J D Tangelder, Hein van Ingen, John G Fort, Jay L Goldstein.   

Abstract

The risk of major ulcer complications on treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase exponentially with age. However, in a pooled analysis of 12 trial arms, the incidence of endoscopic ulcers on treatment with NSAID was found to increase with age in a roughly linear fashion. Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy.

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Year:  2006        PMID： 16887862      PMCID： PMC1856005          DOI： 10.1136/ard.2006.055012

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  5 in total

1.  NSAID gastropathy: the second most deadly rheumatic disease? Epidemiology and risk appraisal.

Authors:  J F Fries
Journal:  J Rheumatol Suppl       Date:  1991-03

Review 2.  Incidence of serious upper gastrointestinal bleeding/perforation in the general population: review of epidemiologic studies.

Authors:  Sonia Hernández-Díaz; Luis Alberto García Rodríguez
Journal:  J Clin Epidemiol       Date:  2002-02       Impact factor: 6.437

3.  Risk factors for serious nonsteroidal-induced gastrointestinal complications: regression analysis of the MUCOSA trial.

Authors:  L S Simon; H T Hatoum; R M Bittman; W T Archambault; R P Polisson
Journal:  Fam Med       Date:  1996-03       Impact factor: 1.756

4.  Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study.

Authors:  T M MacDonald; S V Morant; G C Robinson; M J Shield; M M McGilchrist; F E Murray; D G McDevitt
Journal:  BMJ       Date:  1997-11-22

5.  Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis.

Authors:  Loren Laine; Claire Bombardier; Christopher J Hawkey; Barry Davis; Deborah Shapiro; Christopher Brett; Alise Reicin
Journal:  Gastroenterology       Date:  2002-10       Impact factor: 22.682
  5 in total
  14 in total

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Journal:  Open Rheumatol J       Date:  2012-12-13

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Authors:  John H Peniston; Morris S Gold; Matthew S Wieman; Lawrence K Alwine
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