Literature DB >> 16886726

Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases.

Aleksandra Maruszak1, Katarzyna Gaweda-Walerych, Ireneusz Sołtyszewski, Cezary Zekanowski.   

Abstract

A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions.

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Year:  2006        PMID： 16886726

Source DB:  PubMed          Journal:  Acta Neurobiol Exp (Wars)        ISSN： 0065-1400            Impact factor:   1.579


  6 in total

Review 1.  The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies.

Authors:  Hans-Jürgen Bandelt; Anita Kloss-Brandstätter; Martin B Richards; Yong-Gang Yao; Ian Logan
Journal:  J Hum Genet       Date:  2013-12-05       Impact factor: 3.172

2.  Role of SCOX in determination of Drosophila melanogaster lifespan.

Authors:  Thanh Binh Nguyen; Hiroyuki Ida; Mai Shimamura; Daishi Kitazawa; Shinichi Akao; Hideki Yoshida; Yoshihiro H Inoue; Masamitsu Yamaguchi
Journal:  Am J Cancer Res       Date:  2014-07-16       Impact factor: 6.166

3.  A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity.

Authors:  Toby Andrew; Cassandra D Calloway; Sarah Stuart; Sang Hoon Lee; Raj Gill; Gail Clement; Philip Chowienczyk; Tim D Spector; Ana M Valdes
Journal:  PLoS One       Date:  2011-08-03       Impact factor: 3.240

Review 4.  Parkinson's disease as a result of aging.

Authors:  Manuel Rodriguez; Clara Rodriguez-Sabate; Ingrid Morales; Alberto Sanchez; Magdalena Sabate
Journal:  Aging Cell       Date:  2015-02-09       Impact factor: 9.304

Review 5.  The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.

Authors:  Manuel Rodriguez; Ingrid Morales; Clara Rodriguez-Sabate; Alberto Sanchez; Rafael Castro; Jose Miguel Brito; Magdalena Sabate
Journal:  Front Neuroanat       Date:  2014-08-07       Impact factor: 3.856

Review 6.  A New Insight into an Alternative Therapeutic Approach to Restore Redox Homeostasis and Functional Mitochondria in Neurodegenerative Diseases.

Authors:  Dong-Hoon Hyun; Jaewang Lee
Journal:  Antioxidants (Basel)       Date:  2021-12-21
  6 in total

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