Literature DB >> 1688612

Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.

J Lüdemann1, B Utecht, W L Gross.   

Abstract

The target antigen of anti-neutrophil cytoplasm antibodies (ACPA; also known as ANCA) was isolated by affinity chromatography from supernatants of human neutrophils, stimulated with phorbol ester to induce degranulation. Sequence analysis of the antigen revealed 17 NH2-terminal amino acids (IVGGHEAQPHIRPIYMA), which have considerable sequence homology with known serine proteinases. Investigation of the enzymatic activity showed that the antigen is a neutral serine proteinase that is able to cleave elastin. Since the molecular weight of the antigen, its substrate specificity, and its inhibitor profile reported in this study are identical with those reported recently for proteinase 3, we conclude that ACPA are most probably directed against proteinase 3.

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Year:  1990        PMID： 1688612      PMCID： PMC2187669          DOI： 10.1084/jem.171.1.357

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

1.  Antibodies to components of neutrophil cytoplasm: a new diagnostic tool in patients with Wegener's granulomatosis and systemic vasculitis.

Authors:  K J Parlevliet; S C Henzen-Logmans; P L Oe; W Bronsveld; A J Balm; A J Donker
Journal:  Q J Med       Date:  1988-01

2.  Characterization of elastase associated with granulomatous tissue remodeling.

Authors:  S Izaki; M Okamoto; P S Hsu; W L Epstein; K Fukuyama
Journal:  J Cell Biochem       Date:  1986       Impact factor: 4.429

3.  Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis.

Authors:  C O Savage; C G Winearls; S Jones; P D Marshall; C M Lockwood
Journal:  Lancet       Date:  1987-06-20       Impact factor: 79.321

4.  Anticytoplasmic antibodies in Wegener's granulomatosis.

Authors:  W L Gross; G Lüdemann; G Kiefer; H Lehmann
Journal:  Lancet       Date:  1986-04-05       Impact factor: 79.321

5.  Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

Authors:  R C Kao; N G Wehner; K M Skubitz; B H Gray; J R Hoidal
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

6.  Detection and quantitation of anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis by ELISA using affinity-purified antigen.

Authors:  J Lüdemann; B Utecht; W L Gross
Journal:  J Immunol Methods       Date:  1988-11-10       Impact factor: 2.303

7.  Characterization of three serine esterases isolated from human IL-2 activated killer cells.

Authors:  A Hameed; D M Lowrey; M Lichtenheld; E R Podack
Journal:  J Immunol       Date:  1988-11-01       Impact factor: 5.422

8.  Amino acid sequence of a mouse mucosal mast cell protease.

Authors:  H L Trong; G F Newlands; H R Miller; H Charbonneau; H Neurath; R G Woodbury
Journal:  Biochemistry       Date:  1989-01-10       Impact factor: 3.162

9.  Primary structure of human neutrophil elastase.

Authors:  S Sinha; W Watorek; S Karr; J Giles; W Bode; J Travis
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

10.  Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis.

Authors:  F J van der Woude; N Rasmussen; S Lobatto; A Wiik; H Permin; L A van Es; M van der Giessen; G K van der Hem; T H The
Journal:  Lancet       Date:  1985-02-23       Impact factor: 79.321
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  96 in total

1.  Autoantibodies to molecular targets in neutrophils in patients with ulcerative colitis.

Authors:  J Brimnes; O H Nielsen; A Wiik; N H Heegaard
Journal:  Dig Dis Sci       Date:  1999-02       Impact factor: 3.199

2.  Anti-platelet autoantibodies from ITP patients recognize an epitope in GPIIb/IIIa deduced by complementary hydropathy.

Authors:  S J De Souza; J Sabbaga; E D'Amico; R Pasqualini; R Brentani
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397

3.  Urinary bladder cancer in Wegener's granulomatosis: is it more than cyclophosphamide?

Authors:  B Hellmich; I Kausch; C Doehn; D Jocham; K Holl-Ulrich; W L Gross
Journal:  Ann Rheum Dis       Date:  2004-10       Impact factor: 19.103

Review 4.  The antigenic significance and methods of detection of the anti-neutrophil cytoplasmic autoantibodies (ANCA).

Authors:  X Bosch; R A Asherson
Journal:  Postgrad Med J       Date:  1992-09       Impact factor: 2.401

5.  Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

Authors:  Christopher J Kuckleburg; Sarah B Tilkens; Sentot Santoso; Peter J Newman
Journal:  J Immunol       Date:  2012-01-20       Impact factor: 5.422

6.  [Lest we forget: statement by the German rheumatology society (DGRh) on the national socialist crimes against Jewish colleagues].

Authors:  J Braun; E Genth
Journal:  Z Rheumatol       Date:  2010-11       Impact factor: 1.372

7.  Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies.

Authors:  Y M Van Der Geld; P C Limburg; C G Kallenberg
Journal:  Clin Exp Immunol       Date:  1999-12       Impact factor: 4.330

8.  B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions.

Authors:  J Voswinkel; A Mueller; J A Kraemer; P Lamprecht; K Herlyn; K Holl-Ulrich; A C Feller; S Pitann; A Gause; W L Gross
Journal:  Ann Rheum Dis       Date:  2005-11-16       Impact factor: 19.103

9.  Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis.

Authors:  F Seibold; P Weber; R Klein; P A Berg; K H Wiedmann
Journal:  Gut       Date:  1992-05       Impact factor: 23.059

10.  Anti-neutrophil cytoplasm antibodies (ANCA) in rheumatoid arthritis: relationship to HLA-DR phenotypes, rheumatoid factor, anti-nuclear antibodies and disease severity.

Authors:  E Röther; D Metzger; B Lang; I Melchers; H H Peter
Journal:  Rheumatol Int       Date:  1994       Impact factor: 2.631
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