Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).

Literature DB >> 1688611

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).

S R Burrows¹, T B Sculley, I S Misko, C Schmidt, D J Moss.

Abstract

Epstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). This report is the first description of an EBV target epitope recognized by specific CTL clones.

Entities: Species

Mesh：

Substances：

Year: 1990 PMID： 1688611 PMCID： PMC2187672 DOI： 10.1084/jem.171.1.345

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas.

Authors: L S Young; Q Y Yao; C M Rooney; T B Sculley; D J Moss; H Rupani; G Laux; G W Bornkamm; A B Rickinson
Journal: J Gen Virol Date: 1987-11 Impact factor: 3.891

2. T-cell antigenic sites tend to be amphipathic structures.

Authors: C DeLisi; J A Berzofsky
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

3. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors: R A Houghten
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

4. Expression of Epstein-Barr virus nuclear antigens 3, 4, and 6 are altered in cell lines containing B-type virus.

Authors: T B Sculley; A Apolloni; R Stumm; D J Moss; N Mueller-Lantczh; I S Misko; D A Cooper
Journal: Virology Date: 1989-08 Impact factor: 3.616

5. Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins.

Authors: M Rowe; L S Young; K Cadwallader; L Petti; E Kieff; A B Rickinson
Journal: J Virol Date: 1989-03 Impact factor: 5.103

6. Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

Authors: D A Thorley-Lawson; E S Israelsohn
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

7. Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines.

Authors: M G Masucci; S Torsteindottir; J Colombani; C Brautbar; E Klein; G Klein
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

8. Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants.

Authors: D J Moss; I S Misko; S R Burrows; K Burman; R McCarthy; T B Sculley
Journal: Nature Date: 1988-02-25 Impact factor: 49.962

9. U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2.

Authors: T Dambaugh; K Hennessy; L Chamnankit; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

10. Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.

Authors: C D Gregory; R J Murray; C F Edwards; A B Rickinson
Journal: J Exp Med Date: 1988-06-01 Impact factor: 14.307

61 in total

1. Latent antigen vaccination in a model gammaherpesvirus infection.

Authors: E J Usherwood; K A Ward; M A Blackman; J P Stewart; D L Woodland
Journal: J Virol Date: 2001-09 Impact factor: 5.103

Review 2. The immunology of Epstein-Barr virus infection.

Authors: D J Moss; S R Burrows; S L Silins; I Misko; R Khanna
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-04-29 Impact factor: 6.237

3. Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes: implications for down-regulation of HLA-A11 in Burkitt lymphoma.

Authors: R Gavioli; P O De Campos-Lima; M G Kurilla; E Kieff; G Klein; M G Masucci
Journal: Proc Natl Acad Sci U S A Date: 1992-07-01 Impact factor: 11.205

Review 4. Infectious Mononucleosis.

Authors: Samantha K Dunmire; Kristin A Hogquist; Henry H Balfour
Journal: Curr Top Microbiol Immunol Date: 2015 Impact factor: 4.291

5. An Epstein-Barr virus-specific cytotoxic T-cell epitope present on A- and B-type transformants.

Authors: S R Burrows; I S Misko; T B Sculley; C Schmidt; D J Moss
Journal: J Virol Date: 1990-08 Impact factor: 5.103

6. Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.

Authors: J Sample; L Brooks; C Sample; L Young; M Rowe; C Gregory; A Rickinson; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1991-07-15 Impact factor: 11.205

7. Nonresponsiveness to an immunodominant Epstein-Barr virus-encoded cytotoxic T-lymphocyte epitope in nuclear antigen 3A: implications for vaccine strategies.

Authors: C Schmidt; S R Burrows; T B Sculley; D J Moss; I S Misko
Journal: Proc Natl Acad Sci U S A Date: 1991-11-01 Impact factor: 11.205