Literature DB >> 16886068

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold.

Jenny K Ekegren1, Johan Gising, Hans Wallberg, Mats Larhed, Bertil Samuelsson, Anders Hallberg.   

Abstract

A short synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains has been developed.

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Year:  2006        PMID： 16886068     DOI： 10.1039/b606859f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Authors:  Arun K Ghosh; Ravindra D Jadhav; Hannah Simpson; Satish Kovela; Heather Osswald; Johnson Agniswamy; Yuan-Fang Wang; Shin-Ichiro Hattori; Irene T Weber; Hiroaki Mitsuya
Journal:  Eur J Med Chem       Date:  2018-09-18       Impact factor: 6.514

2.  Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors.

Authors:  Xiongyu Wu; Per Ohrngren; Advait A Joshi; Alejandro Trejos; Magnus Persson; Riina K Arvela; Hans Wallberg; Lotta Vrang; Asa Rosenquist; Bertil B Samuelsson; Johan Unge; Mats Larhed
Journal:  J Med Chem       Date:  2012-03-13       Impact factor: 7.446

3.  Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors.

Authors:  Lucia Lazorova; Ina Hubatsch; Jenny K Ekegren; Johan Gising; Daisuke Nakai; Noha M Zaki; Christel A S Bergström; Ulf Norinder; Mats Larhed; Per Artursson
Journal:  J Pharm Sci       Date:  2011-04-13       Impact factor: 3.534

Review 4.  MAOS and medicinal chemistry: some important examples from the last years.

Authors:  Nailton M Nascimento-Júnior; Arthur E Kümmerle; Eliezer J Barreiro; Carlos A M Fraga
Journal:  Molecules       Date:  2011-11-07       Impact factor: 4.411
  4 in total

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