Literature DB >> 16885694

A hypothesis: is diverticulitis a type of inflammatory bowel disease?

Martin H Floch1.   

Abstract

It is accepted by epidemiologists that diverticula formation in the colon is related to a deficiency in dietary fiber intake, but the cause of acute diverticulitis remains unknown. A hypothesis is presented that acknowledges from the literature that fiber deficiency is also related to an altered intestinal microecology with a change in the bacterial flora. It is hypothesized that the change in the flora with a decrease in their influence on the immune process permits a low-grade chronic inflammation in the mucosa, which is the first step in developing an acute infection of diverticula or diverticulitis. There is some evidence that the low-grade chronic inflammation is present in subjects with diverticula, which is the forerunner of acute diverticulitis. This hypothesis is strengthened by early reports that anti-inflammatory mucosal agents such as mesalamine and immune process regulators such as probiotics may improve diverticulitis.

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Mesh:

Year:  2006        PMID: 16885694     DOI: 10.1097/01.mcg.0000225502.29498.ba

Source DB:  PubMed          Journal:  J Clin Gastroenterol        ISSN: 0192-0790            Impact factor:   3.062


  28 in total

1.  Long-term treatment with mesalazine in patients with symptomatic uncomplicated diverticular disease.

Authors:  Luigi Gatta; Francesco Di Mario; Margherita Curlo; Dino Vaira; Alberto Pilotto; Paolo Lucarini; Maurizio Lera; Kajo Enkleda; Angelo Franzé; Carmelo Scarpignato
Journal:  Intern Emerg Med       Date:  2011-01-29       Impact factor: 3.397

2.  Preventing recurrent acute diverticulitis with pharmacological therapies.

Authors:  Antonio Tursi
Journal:  Ther Adv Chronic Dis       Date:  2013-11       Impact factor: 5.091

3.  Medical treatment of colonic diverticular disease: are we sure the aim is right?

Authors:  Gabrio Bassotti; Vincenzo Villanacci
Journal:  Intern Emerg Med       Date:  2011-03-23       Impact factor: 3.397

4.  Italian consensus conference for colonic diverticulosis and diverticular disease.

Authors:  Rosario Cuomo; Giovanni Barbara; Fabio Pace; Vito Annese; Gabrio Bassotti; Gian Andrea Binda; Tino Casetti; Antonio Colecchia; Davide Festi; Roberto Fiocca; Andrea Laghi; Giovanni Maconi; Riccardo Nascimbeni; Carmelo Scarpignato; Vincenzo Villanacci; Bruno Annibale
Journal:  United European Gastroenterol J       Date:  2014-10       Impact factor: 4.623

Review 5.  Updates in diverticular disease.

Authors:  Adam W Templeton; Lisa L Strate
Journal:  Curr Gastroenterol Rep       Date:  2013-08

Review 6.  Expanding applications: the potential usage of 5-aminosalicylic acid in diverticular disease.

Authors:  Antonio Tursi; Raymond E Joseph; Paul Streck
Journal:  Dig Dis Sci       Date:  2011-05-13       Impact factor: 3.199

7.  Diverticular disease: A therapeutic overview.

Authors:  Antonio Tursi
Journal:  World J Gastrointest Pharmacol Ther       Date:  2010-02-06

8.  Menopausal Hormone Therapy and Risk of Diverticulitis.

Authors:  Manol Jovani; Wenjie Ma; Amit D Joshi; Po-Hong Liu; Long H Nguyen; Yin Cao; Idy Tam; Kana Wu; Edward L Giovannucci; Andrew T Chan; Lisa L Strate
Journal:  Am J Gastroenterol       Date:  2019-02       Impact factor: 10.864

Review 9.  [Prevention and conservative therapy of diverticular disease].

Authors:  E Kruse; L Leifeld
Journal:  Chirurg       Date:  2014-04       Impact factor: 0.955

Review 10.  Probiotics in the management of colonic disorders.

Authors:  Eamonn M M Quigley
Journal:  Curr Gastroenterol Rep       Date:  2007-10
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